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基于生命/影像组学的精准组学放射治疗研究进展 被引量:2

Research Progress of Precise Omics Radiotherapy Based on Life/Imaging Omics
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摘要 恶性肿瘤的发病率和死亡率均较高,基因组测序为肿瘤精准医疗带来了革命性的变化。本文从国内外的研究现状出发,介绍生命组学技术、影像组学的概念和方法框架与人工智能(AI)技术引领的新技术革命。分析精准组学放射治疗的技术优势和全球的研究进展。对基因组学及或影像组学技术可获得肿瘤和个体的遗传信息和生物学特征进行综述,以期为放射治疗适应证评估、治疗方案的制定和放射剂量分配更加准确的提供参考。 The morbidity and mortality of malignant tumors are relatively high,and genome sequencing has brought revolutionary changes to precision medical treatment of tumors.Based on the current research situation at home and abroad,this article introduces the concepts and method framework of life omics technology,imaging omics and the new technology revolution led by artificial intelligence(AI)technology.Analyze the technical advantages of precision omics radiotherapy and global research progress.The genomics and/or imaging technology can obtain the genetic information and biological characteristics of tumors and individuals,in order to provide a more accurate reference for radiotherapy indication evaluation,treatment planning and radiation dose allocation.
作者 蔡凯 黄贵华 CAI Kai;HUANG Gui-hua(Radiotherapy Center,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530021,Guangxi,China)
出处 《医学信息》 2020年第14期27-30,35,共5页 Journal of Medical Information
基金 1.广西卫生健康委员会科研课题(编号:Z20201201) 2.广西贵港市科技攻关项目(编号:贵科攻1407014)。
关键词 生命组学 影像组学 人工智能 放射治疗 Life omics Imaging omics Artificial intelligence Radiotherapy
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  • 1Yu DH, Hung MC. Overexpression of ErbB2 in cancer and ErbB2-targeting Strategies[J]. Oneogene, 2000, 19(53 ) : 6115 -6121.
  • 2Widakowich C, Dinh P, Azambuja ED, et al. HER-2 positive breast cancer: what else beyond trastuzumab-based therapy? [ J ]. Anticancer Agents Med Chem, 2008, 8 (5) : 488-496.
  • 3Shui X, Huang J, Li YH, et al. Construction and selection of Human Fab antibody phage display library of liver cancer[ J ]. Hybridoma, 2009, 28(5) : 341 -347.
  • 4Liu XR, He ZM, Zhou M, et al. Purification and characterization of recombinant extracellular domain of human HER2 from Escherichia coli[ J ]. Protein Expression and Purification, 2007, 53 (2): 247 - 254.
  • 5Kang AS, Butrten DR, Lerner RA, et al. Combinatorial immunoglobulin libraries in phagesλ [ J ]. Methods: Companion Methos Enzymol 1991, 2(2): 111-121.
  • 6Jain M, Kamal N, Batra SK, et al. Engineering antibodies for clinical applications[ J]. Trends in Biotechnology, 2007, 25 ( 7 ) : 307 - 316.
  • 7Kim SJ, Park Y, Hong H J, et al. Antibody engineering for the development of therapeutic antibodies[J]. Mol Cell, 2005, 20( 1 ) : 17 - 29.
  • 8Harris ML, Rosen A. Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies[ J]. Current opinion in rheumatology, 2003, 15(6) : 778 -784.
  • 9Duenas M, Chin LT, Malmborg AC, et al. In vitro immunization of naive human B cells yields high affinity immunoglobulin G antibodies as illustrated by phage display[J]. Immunology, 1996, 89( 1 ) : 1 -7.
  • 10苏会芳,周国锋,谢传淼,蔡培强,张嵘,吴小亮,黎浩江,于行素,范卫君,樊懿,张振峰.放射组学的兴起和研究进展[J].中华医学杂志,2015,95(7):553-556. 被引量:59

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