摘要
目的:探讨重度子痫前期患者胎盘组织中丝氨酸蛋白酶(HtrA4)的表达与围产儿结局关系。方法:招募69例重度子痫前期孕妇(重度子痫组)和50例正常孕妇(对照组),分别进行外周血清、胎盘组织HtrA4检测。分析不同妊娠结局、围产儿结局产妇胎盘组织HtrA4表达差异,Pearson相关系数描述胎盘组织HtrA4表达与新生儿出生体质量、脐血流动力学参数胎儿脐动脉收缩压与舒张压的比值(S/D)、搏动指数(PI)、阻力指数(RI)相关性。结果:重度子痫组HtrA4在血清(169.25±26.58)、胎盘组织中(0.18±0.05)表达均高于对照组(96.25±10.25、0.12±0.01),不良妊娠结局、不良围产儿结局患者血清、胎盘组织中HtrA4表达高于正常妊娠结局者(均P<0.05)。胎盘组织中HtrA4表达与新生儿出生体质量呈负相关(r=-0.478,P<0.05),与S/D值、RI、PI呈正相关(r=0.476、0.540、0.650,P<0.05)。结论:重度子痫前期患者胎盘组织中HtrA4表达明显上调,其表达与妊娠结局、围产儿结局相关。
Objective:To investigate the correlation between the expression of HtrA4 in placenta tissue of women with severe preeclampsia and their perinatal outcomes. Methods: 69 pregnant women with severe preeclampsia were selected in study group and 50 normal pregnant women were selected in control group. The experience of HtrA4 in peripheral blood and placenta tissue of all women were detected. The maternal pregnancy outcomes and the experience differences of HtrA4 in placenta tissue of women in the two groups were analyzed. Pearson correlation coefficient was used to describing the correlation between HtrA4 expression in placenta tissue and neonatal birth weight, umbilical hemodynamic parameters, such as the ratio of fetal umbilical artery systolic pressure to diastolic pressure(S/D), pulsation index(PI), resistance index(RI). Results: The expressions of HtrA4 in the serum and placenta of women with severe eclampsia group were significant higher than those of women in the control group(P<0.05). The expressions of HtrA4 in the serum and placental tissues of women with adverse pregnancy outcomes and poor perinatal outcomes were significant higher than those of normal pregnancy women(P<0.05). There was a negative correlation between HtrA4 expression in placental tissue and neonatal birth weight(r=-0.478, P<0.05). There was a positive correlation between HtrA4 expression in placental tissue and S/D value, RI and PI(r=0.476, 0.540, 0.650, P<0.05). Conclusion: The expression of HtrA4 in placenta tissue of women with severe preeclampsia has up-regulate significantly, which is closely related to pregnancy outcomes and perinatal outcomes.
作者
李发红
韩娜
江楠
许茜
LI Fahong;HAN Na;JIANG Nan;XU Qian(Qingdao Women and Children’s Hospital,Shandong Province,266034)
出处
《中国计划生育学杂志》
2020年第7期1125-1128,共4页
Chinese Journal of Family Planning
