摘要
目的探讨妊娠期间环境大气污染与妊娠期高血压(hypertensive disorders of pregnancy,HDP)之间的关系,为预防和控制HDP的发生提供依据。方法收集国内外已发表的有关妊娠期间大气污染与HDP关系的病例对照研究,进行meta分析。结果经过筛选共纳入15篇文献,纳入患者为妊娠高血压(gestational hypertension,GH)和子痫前期患者。meta分析提示,整个孕期PM10、PM2.5、O3、NO2、CO、NOx暴露与HDP(GH、子痫前期)发生的合并OR值分别为1.06(95%CI:1.04~1.08),1.10(95%CI:1.08~1.13),1.04(95%CI:1.01~1.06),1.10(95%CI:1.07~1.14),1.02(95%CI:0.98~1.06)和1.03(95%CI:0.98~1.07)。对于GH,妊娠早期PM10、PM2.5、O3、NO2暴露的合并OR值分别为1.06(95%CI:1.02~1.10),1.07(95%CI:1.03~1.12),1.04(95%CI:1.01~1.08),1.13(95%CI:1.07~1.19),妊娠全程PM10、NO2暴露的合并OR值分别为1.07(95%CI:1.04~1.11),1.14(95%CI:1.04~1.24)。对于子痫前期,妊娠早期PM10、PM2.5、NO2暴露的合并OR值分别为1.06(95%CI:1.02~1.10),1.27(95%CI:1.07~1.51),1.08(95%CI:1.02~1.14),妊娠全程NO2暴露的合并OR值为1.09(95%CI:1.02~1.17)。结论孕期PM10、PM2.5、O3、NO2暴露可能与HDP(GH和子痫前期)的发生有关。
Objective To understand the association between air pollution and hypertensive disorders of pregnancy(HDP)and provide the evidence for prevention on HDP.Methods Case-control studies regarding association between air pollution and HDP were collected for meta-analysis.Results Fifteen articles on gestational hypertension(GH)and preeclampsia were screened and analyzed.The pooled ORs were 1.06(95%CI:1.04-1.08),1.10(95%CI:1.08-1.13),1.04(95%CI:1.01-1.06),1.10(95%CI:1.07-1.14),1.02(95%CI:0.98-1.06)and 1.03(95%CI:0.98-1.07)for exposure to PM10,PM2.5,O3,NO2,CO and NOxduring entire pregnancy associated with HDP,as well as 1.06(95%CI:1.02-1.10),1.07(95%CI:1.03-1.12),1.04(95%CI:1.01-1.08),1.13(95%CI:1.07-1.19)for PM10,PM2.5,O3 and NO2 during the first pregnancy associated with GH,1.07(95%CI:1.04-1.11)and 1.14(95%CI:1.04-1.24)for PM10 and NO2 during entire pregnancy associated with GH,1.06(95%CI:1.02-1.10),1.27(95%CI:1.07-1.51),1.08(95%CI:1.02-1.14)for PM10,PM2.5 and NO2 during the first pregnancy associated with preeclampsia,1.09(95%CI:1.02-1.17)for NO2 during entire pregnancy associated with preeclampsia,respectively.Conclusion Exposure to PM10,PM2.5,O3 and NO2 during entire pregnancy may induce HDP.
作者
艾玲
朱峻峰
冯冰霜
庄明燕
AI Ling;ZHU Jun-feng;FENG Bing-shuang;ZHUANG Ming-yan(Department of Obstetrics,Yichang Maternal and Child Health Care Hospital,Yichang,Hubei 443000,China)
出处
《环境与健康杂志》
CAS
北大核心
2020年第7期628-634,共7页
Journal of Environment and Health
基金
湖北省卫生健康委员会科研项目(WJ2019F079)
