摘要
肠道黏膜是机体内环境与外界直接交流的主要界面,是机体抵御肠道抗原的第1道防线。肠道屏障功能完整性对维持肠道稳态乃至机体健康至关重要。熊果酸是一类植物来源的五环三萜类化合物。研究发现,熊果酸可以通过影响肠上皮屏障功能、肠道黏蛋白表达、菌群结构和免疫细胞功能等来维护肠道稳态和机体健康。本文对熊果酸调控动物肠道屏障的作用及可能机制作一简要概述,为其在畜牧生产中的应用提供指导。
Intestinal mucosa is the main interface between the internal environment and the outside world,and the first line of defense against intestinal antigens.The integrity of intestinal mucosal barrier function plays an important role in animal intestinal health and the normal physiological functions of the body.Ursolic acid is a class of pentacyclic triterpenoids derived from plants.It was found that ursolic acid can maintain intestinal ho⁃meostasis and body health by affecting intestinal epithelial barrier function,intestinal mucin expression,bacteri⁃al structure and immune cell function.In this paper,the regulation of ursolic acid on intestinal mucosal barrier and its possible mechanism were summarized,which provided theoretical basis for its application in production and clinical practice.
作者
彭芳
宋泽和
谢谦
贺喜
PENG Fang;SONG Zehe;XIE Qian;HE Xi(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Hunan Engineering Research Center of Poultry Production Safety,Hunan Co⁃Innovation Center of Animal Production Safety,Changsha 410128,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2020年第6期2513-2520,共8页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家重点研发计划(2018YFE0101700)
湖南农业大学“双一流”建设项目(SYL201802015,SYL201802009)。
关键词
熊果酸
屏障功能
肠道健康
作用机制
ursolic acid
gut barrier
intestinal health
mechanism
