摘要
目的:观察柴胡加龙骨牡蛎汤加减治疗脑震荡后综合征(PCS)的临床疗效。方法:纳入64例PCS患者,采用随机数字表分为治疗组和对照组,每组32例。两组患者均给予常规对症治疗,在此基础上,治疗组患者予柴胡加龙骨牡蛎汤加减治疗,治疗周期为2个月。采用Rivermead脑震荡后综合征症状问卷评分量表进行患者的临床症状评分,比较两组患者治疗前后的症状总积分,评价临床疗效;采用匹兹堡睡眠质量指数(PSQI)评价患者的睡眠质量;采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评价患者的焦虑、抑郁程度。结果:①治疗后,治疗组的临床总有效率为93.8%,对照组为78.1%,治疗组的疗效优于对照组(P<0.05)。②治疗后,两组患者的症状总积分较治疗前均显著降低(P<0.05),且治疗组患者的积分明显低于对照组(P<0.05)。③治疗后,治疗组患者的PSQI评分较治疗前明显降低(P<0.05),且治疗组患者的PSQI评分低于对照组(P<0.05)。④治疗后,治疗组患者的焦虑、抑郁程度较治疗前明显改善(P<0.05),且治疗组患者的焦虑、抑郁程度优于对照组(P<0.05)。结论:柴胡加龙骨牡蛎汤加减治疗PCS,能够有效改善患者的症状、睡眠及焦虑、抑郁情绪,值得进一步研究。
Objective: To observe the clinical efficacy of modified Chaihu plus Longgu Muli Decoction in the treatment of post-concussion syndrome(PCS). Methods: Sixty-four patients with PCS were included and randomly divided into the treatment group and control group according to random number table, 32 cases in each group. The patients in both groups were treated with conventional symptomatic treatment, and the patients in the treatment group were treated with modified Chaihu plus Longgu Muli Decoction based on above, with a course of 2 months. The clinical symptom scores were evaluated by Rivermead post-concussion syndrome symptom questionnaire, the total scores of symptoms were compared between the two groups before and after treatment, and the clinical efficacy was evaluated. The sleep quality was evaluated by Pittsburgh sleep quality index(PSQI). The degrees of anxiety and depression were evaluated by self-rating anxiety scale(SAS) and self-rating depression scale(SDS). Results: ①After treatment, the total clinical effective rates of the treatment group and the control group were 93.8% and 78.1% respectively, and the efficacy of the treatment group was better than that of the control group(P<0.05). ②After treatment, the total score of symptoms was significantly decreased in both groups compared with that before treatment(P<0.05), and the total score of the treatment group was significantly lower than that of the control group(P<0.05).(3)After treatment,the PSQI score of the treatment group was significantly decreased compared with that before treatment(P<0.05),and the PSQI score of the treatment group was lower than that of the control group(P<0.05).(4)After treatment,the anxiety and depression of the patients in the treatment group were significantly improved compared with that before treatment(P<0.05),and the degrees of anxiety and depression in the treatment group were better than those in the control group(P<0.05).Conclusion: Modified Chaihu plus Longgu Muli Decoction can effectively improve the symptoms,sleep,and emotions of anxiety and depression in patients with PCS,which is worthy of further research.
作者
邱锋
夏振威
蔡佩浩
顾国山
王静予
许乐宜
孔令军
费智敏
龚立
QIU Feng;XIA Zhenwei;CAI Peihao;GU Guoshan;WANG Jingyu;XU Leyi;KONG Lingjun;FEI Zhimin;GONG Li(Department of Neurosurgery,Shuguang Hospital Affiliated to Shanghai University of Traditiontil Chinese Medicine,Shanghai 201203,China;Department of Integrated Traditional Chinese and Western Medicine,Shanghai Oriental Hepatobiliary Surgeiy Hospital,Shanghcii 201805,China)
出处
《上海中医药大学学报》
CAS
2020年第3期22-25,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海中医药大学预算内项目(2019LK018)。
关键词
脑震荡后综合征
柴胡加龙骨牡蛎汤
中医药疗法
post-concussion syndrome
Chaihu plus Longgu Muli Decoction
Chinese medical therapy
