摘要
目的探究分析坤泰胶囊对更年期综合征伴失眠患者心理状态及睡眠质量的影响。方法选取2017年1月-2019年2月沈阳市妇幼保健院就诊的更年期综合征伴失眠患者70例作为临床研究对象,采用随机数字表法将研究对象随机分为对照组和试验组两组,35例对照组口服芬吗通,1片/次,1次/d;在对照组基础上,35例试验组口服坤泰胶囊,2.0 g/次,2次/d,两组患者均连续用药3个疗程。观察两组患者治疗前后汉密顿焦虑量表(Hamilton Anxiety Scale,HAMA)、汉密顿抑郁量表(Hamilton Depression Scale,HAMD)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)及更年期Kupperman评分情况变化,综合比较两组患者的临床疗效。结果坤泰胶囊干预前,两组患者HAMA及HAMD量表评分组间比较无统计学差异(P>0.05),治疗后试验组HAMA及HAMD量表评分明显低于对照组(P<0.05)。干预前两组患者PSQI量表各项评分组间比较无明显差异(P>0.05),药物干预后试验组睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍等PSQI量表各项评分均明显低于对照组(P<0.05)。治疗前,试验组和对照组更年期Kupperman评分比较无明显统计学差异(P>0.05),治疗后试验组更年期Kupperman评分则明显低于对照组(P<0.05)。治疗后试验组总有效率为88.57%,对照组总有效率为77.14%,明显低于试验组(P<0.05),组间差异显著,具有统计学意义。结论坤泰胶囊联合芬吗通能有效改善更年期综合征伴失眠患者的不良情绪状态,保障睡眠质量,临床疗效显著。
Objective To explore the effects of Kuntai Capsule on mental state and sleep quality of menopausal syndrome with insomnia. Methods A total of 70 cases of menopausal syndrome patients with insomnia treated in our hospital from 2016 January to 2019 February were selected for the study and divided into the control group and the observation group according to the random number table method. 35 cases in the control group was treated with Femoston,whereas 35 cases in the observation group was given Femoston with Kuntai Capsule. After 3 courses of treatment,Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Pittsburgh Sleep Quality Index(PSQI)scale and the Kupperman score of the two groups and the untoward effect were compared. Meanwhile,the clinical eficacy of the two groups was compared after treatment. Results After treatment,the scores of HAMA and HAMD in the obseration group,which were significantly lower than those in the control group(P<0.05). After treatment,the PSQI score in the observation group was significantly lower than that in the control group(P<0.05). The scores of Kupperman in the observation group were significantly lower than those in the control group(P<0.05). The total efective rate of clinical symptoms improvement was 77.14% in the control group,which was significantly lower than that in the observation group with 88.57%(P<0.05). Conclusion Kuntai Capsule combined with Femoston as a good clinical efficacy has a good clinical efficacy,can significantly improve anxiety and depression symptoms and the sleep quality in the treatment of menopausal syndrome patients with insomnia.
作者
李娴彧
LI Xianyu(Shenyang Maternity and Child Health Hospital,Shenyang 110014,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2020年第4期162-165,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
沈阳市科技计划项目(18-014-4-92)。
