摘要
目的分析脑型肝豆状核变性(WD)患者临床特征及实验室指标的性别差异性。方法选取我院2018年6月~2019年12月收治的120例脑型WD患者为研究对象进行回顾性分析,按照性别划分为男性组(n=75)与女性组(n=45),对两组患者的发病年龄、病情严重程度、临床分型、血尿酸、铜生化及治疗前24 h尿铜等实验室检查指标进行评价和对比。结果男性组发病年龄多在青少年期和青年期,而女性组发病年龄多在学龄期与青年期,差异有统计学意义(P<0.05);男性组在临床分型上扭转痉挛型占比高于女性组,差异有统计学意义(P<0.05);男性组在UMDRS评分、治疗前24 h尿铜均比女性组更高,而血尿酸水平比女性组低,差异有统计学意义(P<0.05)。结论脑型WD患者在性别上存在明显差异,主要表现在发病年龄、病情严重程度、治疗前24 h尿铜、临床分型及尿酸等方面,临床可根据性别差异性采用个体化治疗方案,以取得更好的预后效果。
Objective To analyze the gender differences in clinical characteristics and laboratory parameters of patients with cerebral type hepatolenticular degeneration(WD).Methods 120 patients with cerebral WD treated in our hospital from June 2018 to December 2019 were retrospectively analyzed.They were divided into male group(n=75)and female group(n=45)by gender.The laboratory indicators such as age of onset,severity of disease,clinical classification,blood uric acid,copper biochemistry,and 24-hour urine copper before treatment were evaluated and compared.Results The age of onset in the male group was mostly from adolescence and adolescence,while the age of onset in the female group was mostly from school age and adolescence,with statistically significant difference(P<0.05).The male group had a higher proportion of torsion spasm in clinical classification than the female group,and the difference was statistically significant(P<0.05).The UMDRS score and the 24-hour urinary copper in the male group were higher than those in the female group,and the blood uric acid level in the male group was lower than that in the female group,and the difference was statistically significant(P<0.05).Conclusion There are significant gender differences in the age of onset,severity of illness,urinary copper,clinical classification,and uric acid in patients with cerebral type WD.Individualized treatment can be adopted clinically according to gender differences in order to achieve better prognosis.
作者
施升升
赖晓东
卢美珍
阳清伟
陈星宇
SHI Shengsheng;LAI Xiaodong;LU Meizhen;YANG Qingwei;CHEN Xingyu(Department of Neurology,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004,China;Fuzhou Medical College,Nanchang University,Fuzhou 344000,China;Department of Radiation Oncology,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004,China)
出处
《中国现代医生》
2020年第11期47-49,共3页
China Modern Doctor
基金
福建省卫计委青年科研课题资助项目(2014-2-70)
福建省自然科学基金资助项目(2019J01561)。
关键词
脑型肝豆状核变性
性别差异性
临床特征
实验室指标
尿铜
尿酸
Cerebral-type hepatolenticular degeneration
Gender differences
Clinical characteristics
Laboratory indicators
Urine copper
Uric acid
