摘要
目的探讨系统性红斑狼疮(SLE)患儿的临床特点。方法对2014年1月至2019年1月于本科初发确诊的37例SLE患儿首次住院病史进行回顾性分析。结果37例患儿中,男7例,女30例,年龄(10.46±2.36)岁。首发症状以发热(67.57%)、面部皮疹(64.86%)、关节肿痛(45.95%)、浆膜炎(32.43%)多见,81.08%的患儿存在血液系统受累,64.86%的患儿累及肾脏;实验室检查:ANA阳性33例(89.19%),C3下降29例(78.38%),C4下降28例(75.68%),贫血25例(67.57%),血沉快25例(67.57%),蛋白尿24例(64.86%),白细胞减少21例(56.76%),抗双链DNA抗体阳性16例(43.24%),肝功能异常13例(35.14%),抗SSA抗体阳性12例(32.43%),抗Sm抗体阳性11例(29.73%)。男性患儿肾脏损伤、抗双链DNA抗体阳性率、抗核小体抗体阳性率均显著高于女性(均P<0.05)。结论儿童SLE女性多见,血液系统、肾脏累及率最高,男性患儿易出现肾脏损伤,以蛋白尿最常见,抗核小体抗体是男性患儿疾病活动度高于女性的危险因素。
Objective To investigate the clinical features of pediatric patients with systemic lupus erythematosus(SLE).Methods The medical record of 37 pediatric patients with SLE in the first time hospitalization were retrospectively reviewed between Jan.,2014 and Jan.,2019.Results Of the 37 cases,7 were male,and 30 female.They were(10.46±2.36)years old.The common symptoms found for the first time were fever(67.57%),facial rash(64.86%),joint pain(45.95%),and serositis(32.43%).The hematologic system cumulative percentage was high(81.08%).Among them,24 patients(64.86%)had renal involvement.The laboratory tests showed that 33 cases(89.19%)were positive in ANA;29 cases(78.38%)had a decrease in C3 complement and 28 cases(75.68%)in C4 complement;25 cases(67.57%)got anemia;25 cases(67.57%)had fast ESR;24 cases(64.86%)had proteinuria;21 cases(56.76%)got a decrease in leukocyte;16 cases(43.24%)were positive in antidsDNA antibody;13 cases(35.14%)hd abnormal liver function;and 12 cases(32.43%)were positive in anti-SSA antibody and 11 cases(29.73%)in anti-Sm antibody.The renal injury,anti-dsDNA antibody,and anti-nucleosome antibody of the male children with SLE were significantly higher than those of the female children(all P<0.05).Conclusion SLE is more common in girls,with the highest involvement rate of blood system and kidney.Male children with SLE are easy to appear renal injury,and proteinuria is the most common.Anti-nucleosome antibody is a risk factor causing a higher incidence of SLE disease activity in male than in female children.
作者
刘玉洁
李玉柳
张书锋
刘翠华
Liu Yujie;Li Yuliu;Zhang Shufeng;Liu Cuihua(Department of Nephrology and Rheumatology,Children’s Hospital Affiliated to Zhengzhou University(Henan Children’s Hospital,Zhengzhou Children’s Hospital),Zhengzhou 450000,China.)
出处
《国际医药卫生导报》
2020年第12期1681-1683,1704,共4页
International Medicine and Health Guidance News
基金
2018年河南省医学科技攻关计划(2018020663)。
关键词
系统性红斑狼疮
儿童
临床特点
Systemic lupus erythematosus
Children
Clinical features
