摘要
目的研究小儿复方氨基酸注射液(18AA-Ⅱ)联合消旋卡多曲颗粒治疗轮状病毒肠炎患儿的临床效果。方法选取2017年3月~2018年1月我院收治的150例轮状病毒肠炎患儿为研究对象,按随机数字表法将其分为试验组(n=75)和对照组(n=75)。对照组采用常规抗炎抗病毒补液治疗,试验组在对照组的基础上采用18AA-Ⅱ联合消旋卡多曲颗粒治疗。比较两组的临床治疗效果、临床症状改善时间及不同时间血清C反应蛋白(CRP)水平。结果治疗后,试验组临床总有效率为90.67%,高于对照组的76.00%,差异有统计学意义(P<0.05);试验组纠正脱水时间、止泻时间、退热时间和止吐时间短于对照组,差异均有统计学意义(P<0.05);试验组治疗后24、48、72 h CRP水平低于对照组,差异有统计学意义(P<0.05)。结论 18AA-Ⅱ联合消旋卡多曲颗粒治疗轮状病毒肠炎患儿的临床效果好,可缩短患儿症状缓解时间,增强抗炎效果。
Objective To study the clinical effect of Pediatric Compound Amino Acid Injection(18 AA-Ⅱ) combined with Racecadotril Granules on children with rotavirus enteritis. Methods A total of 150 children with rotavirus enteritis treated in our hospital from March 2017 to January 2018 were selected as study subjects. They were divided into test group(n=75) and control group(n=75) by random number table method. The children in the control group were treated with conventional anti-inflammatory and antiviral and fluid replacement. The test group was treated with 18 AA-Ⅱ with Racecadotril Granules on the basis of conventional treatment. The clinical effect, clinical symptom improvement time and serum C-reactive protein(CRP) levels at different periods of the two groups were compared. Results After treatment, the total clinical effective rate of patients in the test group was 90.67%, higher than that of the control group accounting for 76.00%, the difference was statistically significant(P<0.05). The corrected dehydration time, antidiarrheal time, antipyretic time and vomiting stopping time in the test group were shorter than those in the control group, the differences were statistically significant(P<0.05). CRP levels of the children in the test group at 24, 48, and 72 h after treatments were lower than those in the control group, the difference was statistically significant(P<0.05). Conclusion The 18 AA-Ⅱcombined with Racecadotril Granules in children with rotavirus enteritis has a good clinical effect, which can effectively shorten the symptom relief time and enhance the anti-inflammatory effect.
作者
吴元芳
黄惠仪
余淑娟
WU Yuan-fang;HUANG Hui-yi;YU Shu-juan(Department of Pediatrics,Kaiping Central Hospital,Guangdong Province,Kaiping529300,China)
出处
《中国当代医药》
2020年第10期133-135,共3页
China Modern Medicine
