摘要
目的:观察葡萄糖酸锌治疗轮状病毒腹泻患儿的效果。方法:选取收治的72例轮状病毒腹泻患儿为研究对象,采用随机数字表法分为观察组和对照组各36例。对照组采用补液、微生态制剂、蒙脱石散等对症治疗,观察组在对照组的基础上联合葡萄糖酸锌治疗,比较两组治疗前后的补体3(C3)、C4、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、可溶性白介素-2受体(s IL-2R)、白细胞介素8(IL-8)、白细胞介素1β(IL-1β)及肿瘤坏死因子α(TNF-α)水平,治疗总有效率、治愈时间及纠正脱水时间。结果:治疗后,两组患儿C3、C4、IgA及IgG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组sl L-2R、IL-8、IL-1β及TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗有效率为97.22%,高于对照组的77.78%,差异有统计学意义(P<0.05);观察组治愈时间、纠正脱水时间均短于对照组,差异有统计学意义(P<0.05)。结论:在对症治疗基础上采用葡萄糖酸锌治疗轮状病毒腹泻患儿可提高治疗有效率,改善免疫细胞因子水平,缩短治愈及纠正脱水时间,效果优于单纯对症治疗效果。
Objective: To investigate effects of Zinc gluconate in treatment of children with rotavirus diarrhea. Methods: 72 children with rotavirus diarrhea were selected as the research subjects, and were divided into observation group(n=36) and control group(n=36) by using the random number table method. The control group received symptomatic treatment such as fluid infusion, micro-ecological agents, and montmorillonite powder, while the observation group was treated with Zinc gluconate on the basis of those of the control group. Then, the levels of complement 3(C3) and C4, immunoglobulin A(IgA), immunoglobulin G(IgG), soluble interleukin-2 receptor(sIL-2R), interleukin 8(IL-8), interleukin 1β(IL-1β) and tumor necrosis factor α(TNF-α) before and after the treatment, total treatment effective rate, cure time and correct dehydration time were compared between the two groups.. Results: After the treatment, the levels of C3, C4, IgA and IgG in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05). After the treatment, the levels of slL-2 R, IL-8, IL-1β and TNF-α in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05). The effective rate in the observation group was 97.22%, which was higher than 77.78% in the control group, and the difference was statistically significant(P<0.05). Further, the cure time and correction dehydration time of the observation group were shorter than those of the control group, and the differences were statistically significant(P<0.05). Conclusions: On the basis of symptomatic treatment, Zinc gluconate in the treatment of the children with rotavirus diarrhea can improve the treatment effective rate, improve the levels of immune cytokines, and shorten the cure time and correct dehydration time. Moreover, it is superior to single symptomatic treatment.
作者
王宏刚
WANG Honggang(Heishan County Maternal and Child Health Hospital,Jinzhou 121400 Liaoning,China)
出处
《中国民康医学》
2020年第5期24-25,28,共3页
Medical Journal of Chinese People’s Health
关键词
细胞免疫学
轮状病毒腹泻
葡萄糖酸锌
Cellular immunology
Children with rotavirus diarrhea
Zinc gluconate
