摘要
目的探讨肾乳头状腺瘤(RPA)的临床病理学特征,以提高病理学诊断水平。方法收集2例存档RPA病例,采用HE光镜观察及免疫组织化学EnVision法染色方法,对其临床病理学特征进行分析。结果2例均为女性患者,年龄39岁和54岁。肿瘤直径为0.3 cm和1.3 cm。镜下肿瘤乳头状生长,部分区域管状生长。乳头被覆细胞立方状,细胞质嗜酸性或嗜碱性,细胞核圆形或卵圆形,无或轻度异型性,染色质细腻,未见明显核仁,缺乏核分裂象。乳头间质血管玻璃样变,灶状淋巴细胞浸润。免疫组化:AMACR(+)、CK7(+)、Ki-67(小于5%)。结论RPA病理学诊断的关键指标是该肿瘤的直径不大于1.5cm。PRA应该与多种具有乳头状生长方式的肾细胞肿瘤进行鉴别。
Objective To explore clinicopathological characteristics of renal papillary adenoma(RPA)and to improve the level of pathological diagnosis.Methods Two archived cases of RPA was collected,was performed with conventional histopathological and immunohistochemical staining,clinicapathological features were analyzed.Results Two patients were female with age of 39 years and 45 years separately.The diameter of tumor in two patients was 0.3 centimeter and 1.3 centimeter.Microscopically,the tumor cells arranged in papillary formation and partly in tubular formation.Papilla was lined by cuboidal cells,with eosinophilic and basophilic cytoplasm,round or ovoid nuclei which was no or mild atypia,fine chromatin,prominent nucleoli are not seen,absence of mitotic figures.The mesenchyme of papilla demonstrated hyaline degeneration of vascular wall and focal infiltration of lymphocyte.Immunophenotypically,the tumor cells were positive for AMACR and CK7,the Ki-67 was less than 5%.Conclusion The key point of pathological diagnosis of RPA was the diameter of the tumor,the standard of the diameter was less than 1.5 centimeter.The differential diagnosis should be made between RPA and other tumors with papillary growth pattern.
作者
姜黄
王功伟
沈丹华
JIANG Huang;WANG Gongwei;SHEN Danhua(The People's Hospital of Zhengzhou,Zhengzhou,450003)
出处
《实用癌症杂志》
2020年第4期612-614,共3页
The Practical Journal of Cancer
关键词
肾肿瘤
乳头状腺瘤
鉴别诊断
Renal tumor
Renal papillary adenoma
Differential diagnosis
