摘要
目的探讨清晨关期(early-morning off, EMO)对早期帕金森病(Parkinson’s disease, PD)患者生活质量的影响。方法 60例原发性早期PD患者,根据是否出现EMO分为EMO组30例和无EMO组30例。采用PD统一评分量表(Unified Parkinson’s Disease Rating Scale, UPDRS)、Hoehn-Yahr(H-Y)分级评估病情严重程度,采用PD生活质量量表(39-Item-Parkinson’s Disease Questionnaire, PDQ-39)评测患者生活质量,采用简易精神状态检查量表(Mini-mental State Examination, MMSE)评估患者精神状态,采用汉密尔顿焦虑量表(14-Item Hamilton Anxiety Rating Scale, HAMA-14)、汉密尔顿抑郁量表(24-Item Hamilton Depression Rating Scale, HAMD-24, HAMD-24)、帕金森病睡眠量表(Parkinson’s Disease Sleep Scale, PDSS)、帕金森病非运动症状评价量表(Non-motor Symptoms Scale, NMSS)、Epworth思睡量表(Epworth Sleepiness Scale, ESS)等对其非运动症状进行评估。比较2组患者一般临床资料,采用多元线性回归分析影响早期PD患者生活质量的相关因素。结果 EMO组H-Y分级[1.5(1.0,2.0)级]高于无EMO组[1.0(1.0,1.5)级](P>0.05),患者PDQ-39评分[(40.8±20.7)分]、UPDRSⅠ评分[(5.1±2.2)分]、UPDRSⅡ评分[(12.8±6.1)分]、UPDRS总分[(34.1±16.8)分]、NMSS评分[(61.8±38.1)分]、ESS评分[(8.3±5.0)分]和左旋多巴每日等效剂量[(701.4±438.2)mg]均明显高于无EMO组[(14.4±11.0)、(2.9±2.2)、(8.8±3.4)、(25.3±9.0)、(35.4±25.6)、(4.6±4.5)分、(466.8±344.3)mg],PDSS评分[(108.0±21.3)分]低于无EMO组[(128.6±24.8)分](P<0.05),UPDRSⅢ、UPDRSⅣ、HAMA-14、HAMD-24、MMSE评分与无EMO组比较差异均无统计学意义(P>0.05);对PDQ-39影响程度最大的为H-Y 2.5级,其次依次为EMO、H-Y 1级、UPDRSⅣ和PDSS(P<0.05)。结论 EMO明显影响早期PD患者的生活质量。
Objective To explore the impact of early-morning off(EMO) on quality of life in early Parkinson’s disease(PD) patients. Methods Sixty patients with primary early PD were divided into EMO group and non-EMO group, with 30 patients in each group. The severity of disease was evaluated by Unified Parkinson’s Disease Rating Scale(UPDRS) and Hoehn-Yahr Staging Scale. The quality of life was assessed by 39-Item-Parkinson’s Disease Questionnaire(PDQ-39). The mental state was assessed by Mini-mental State Examination Scale(MMSE). The non-motor symptoms were assessed by 14-Item Hamilton Anxiety Rating Scale(HAMA-14), 24-Item Hamilton Depression Rating Scale(HAMD-24), Parkinson’s Disease Sleep Scale(PDSS), Non-motor Symptoms Scale(NMSS) and Epworth Sleepiness Scale(ESS), respectively. The general clinical data were compared between two groups. The correlation factors of quality of life were evaluated by multiple linear regression analysis. Results EMO group had higher Hoehn-Yahr Staging Scale(1.5(1.0, 2.0)), PDQ-39 score(40.8±20.7), UPDRSⅠ score(5.1±2.2), UPDRSⅡ score(12.8±6.1), UPDRS score(34.1±16.8), NMSS score(61.8±38.1) and ESS score(8.3±5.0), larger levodopa equivalent daily dose((701.4±438.2) mg) and lower PDSS score(108.0±21.3) than non-EMO group(1.0(1.0, 1.5), 14.4±11.0, 2.9±2.2, 8.8±3.4, 25.3±9.0, 35.4±25.6, 4.6±4.5,(466.8±344.3) mg, 128.6±24.8)(P<0.05). There were no significant differences in UPDRS Ⅲ,UPDRS Ⅳ,HAMA-14,HAMD-24 and MMSE scores between two groups(P>0.05).The factor affecting PDQ most greatly was Hoehn-Yahr Staging Scale 2.5,followed by EMO,1,UPDRSⅣand PDSS score(P<0.05).Conclusion EMO significantly affects the quality of life of early PD patients.
作者
李林忆
闫维维
马建军
赵振向
古祺
陈思远
黄珅
胡世玉
LI Linyi;YAN Weiwei;MA Jianjun;ZHAO Zhenxiang;GU Qi;CHEN Siyuan;HUANG Shen;HU Shiyu(Department of Neurology,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhengzhou 450003,China)
出处
《中华实用诊断与治疗杂志》
2020年第2期148-151,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省科技发展计划项目(192102310085)
河南省医学科技攻关计划项目(201701018)。
关键词
帕金森病
清晨关期
生活质量
非运动症状
Parkinson’s disease
early-morning off
quality of life
non-motor symptoms
