摘要
目的通过分析2010~2018年杭州市门诊及住院患者甲型病毒性肝炎感染情况,为制定甲肝防治策略提供科学依据。方法对2010年1月~2018年12月来本院就诊的470702例住院及门诊患者的血清样本进行甲型病毒性肝炎IgM抗体(抗-HAVIgM)、丙氨酸氨基转移酶(ALT)、总胆红素(TBil)、直接胆红素(DBil)检测,并进行统计分析。结果2010~2018年间甲型病毒性肝炎IgM抗体总阳性率为0.22%(1033/407020),各年间阳性率差异具有统计学意义(P<0.05)。其中男性就诊患者168963例,阳性率为0.28%(476/168963);女性就诊患者301739例,阳性率为0.18%(557/301739)。2010~2018年抗-HAVIgM总阳性率男性高于女性,差异有统计学意义(χ~2=46.439,P<0.05)。>20岁各组阳性构成比均>5%,显著高于<20岁各组,差异有统计学意义(χ~2=208.947,P<0.05)。结论本地区成年人甲型肝炎检出率明显高于未成年人,应当加强对成年人甲肝防治工作,加强健康知识教育,降低感染率,提高人口素质。
Objective To provide a scientific basis for the development of hepatitis A prevention and treatment strategy by analyzing the infection status of viral hepatitis type A in outpatients and hospitalized patients in Hangzhou from2010 to 2018.Methods The serum samples of 470702 inpatients and outpatients who were admitted to our hospital from January 2010 to February 2018 were tested for IgM antibody(anti-HAVIgM)of viral hepatitis type A,alanine aminotransferase(ALT),total Bilirubin(TBil),direct bilirubin(DBil)detection,and statistical analysis was performed.Results The total positive rate of IgM antibody in viral hepatitis A was 0.22%(1033/407020)between 2010 and 2018.The difference in positive rate of each year was statistically significant(P<0.05).Among them,168963 male patients were treated,and the positive rate was 0.28%(476/168963);301,739 female patients were treated,and the positive rate was 0.18%(557/301739).The total positive rate of anti-HAVIgM in 2010-2018 was higher in men than that in women,and the difference was statistically significant(χ2=46.439,P<0.05).The positive composition ratio of>20 years old group was>5%,which was significantly higher than that of<20 years old group,and the difference was statistically significant(χ2=208.947,P<0.05).Conclusion The detection rate of hepatitis A in adults in this region is significantly higher than that of minors.It is necessary to strengthen the prevention and treatment of hepatitis A in adults,strengthen health knowledge education,reduce the infection rate and improve the quality of the population.
作者
倪爱青
何大强
卢珍
NI Aiqing;HE Daqiang;LU Zhen(Department of Clinical Laboratory,Hangzhou First People's Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou310006,China;Department of Clinical Laboratory,Hangzhou Women's Hospital,Hangzhou310008,China)
出处
《中国现代医生》
2020年第3期152-155,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2019RC235)。
