摘要
病毒性肝炎是肝硬化、肝癌事件的重要诱因,已经成为了全球重大公共卫生问题。中药治疗病毒性肝炎具有独特的优势,能够抑制病毒复制,增强机体免疫力,有效防止肝脏纤维化与癌变,对肝功能和症状的改善效果显著,临床疗效确切,安全性较高且不易产生抗药性,减轻西药不良反应,达到增效减毒的效果,同时降低患者停药后的复发率。中药治疗病毒性肝炎的研究备受关注,在实验研究与临床方面取得重大进展。该文系统梳理了近5年来中药治疗病毒性肝炎的国内外研究进展,现代研究证实中药可通过直接或间接抑制病毒、抗炎、抗纤维化、抗氧化、调节免疫、调节自噬及通过其他信号通路发挥了治疗病毒性肝炎的作用。临床上多以中药复方或联合西药使用以此改善患者乏力、食欲不振等临床症状,改善机体免疫机制,增强抗病毒能力,缩短患者的治疗疗程并改善其生活质量。上述研究为病毒性肝炎病的药理研究、临床研究和新药研发提供参考与借鉴。
Viral hepatitis is an important cause of liver cirrhosis and liver cancer,which has become a major public health problem in the world.Traditional Chinese medicine has unique advantages in treating viral hepatitis,which can inhibit virus replication and enhance immunity.It can effectively prevent liver fibrosis and canceration,improving liver function and symptoms significantly with definite clinical curative effects,a high level of safety,and seldom drug resistance.In addition,it reduces the side effects of western medicine,achieving the effect of synergy and attenuation while reducing the recurrence rate of patients after drug withdrawal.Attention has been paid to the research on the treatment of viral hepatitis with traditional Chinese medicine,and great progress has been made in experimental research and clinical practice.In this paper,the research progress of traditional Chinese medicine in the treatment of viral hepatitis at home and abroad in recent five years was systematically reviewed.Modern research has confirmed that traditional Chinese medicine can play a role in the treatment of viral hepatitis by directly or indirectly inhibiting the virus,anti-inflammatory,antifibrosis,anti-oxidation,regulating immunity,regulating autophagy,and other signal pathways.In clinics,traditional Chinese medicine compound or combined with western medicine is often adopted to ameliorate the clinical symptoms of patients such as fatigue and loss of appetite,improve the immune mechanism of the body,enhance the antiviral ability,shorten the treatment course of patients and improve their quality of life.The research provides a reference for pharmacological research,clinical research,and new drug development for viral hepatitis.
作者
封晓洁
于俊杰
隋营营
王丽娜
孟凡刚
FENG Xiaojie;YU Junjie;SUI Yingying;WANG Lina;MENG Fangang(The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Qingdao Traditional Chinese Medicine Hospital,Qingdao 266034,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第13期289-298,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中央引导地方科技发展资金项目(YDZX2021050)
山东省科技型中小企业创新能力提升工程项目(2022TSGC1359)。
关键词
病毒性肝炎
中药治疗
药理研究
临床研究
viral hepatitis
Chinese medicine treatment
pharmacological research
clinical research
