期刊文献+

二肽基肽酶-4抑制剂治疗糖尿病血管损伤研究进展 被引量:7

Research progress of dipeptidyl peptidase-4 inhibitor in the treatment of diabetic vascular injury
暂未订购
导出
摘要 二肽基肽酶-4(dipeptidyl peptidase 4,DPP-4)抑制剂是一类新型的口服降糖药物,它不仅能够抑制DPP-4提高内源性肠促胰素,起到降低血糖的作用,还能通过非血糖依赖途径发挥独特的心血管保护作用包括动脉粥样硬化及血管再狭窄,改善血管内皮或平滑肌功能。本文就常用的DPP-4抑制剂在糖尿病血管损伤方面的研究新进展作综述。 Dipeptidyl peptidase-4(DPP-4)inhibitor is a new class of oral hypoglycemic agents that not only decreases blood glucose through increasing endogenous incretin and inhibiting DPP-4,but also plays an unique role in cardiovascular protection through non-glycemic-dependent pathways in atherosclerosis and restenosis,thus improving the function of vascular endothelial or smooth muscle.
作者 张文旭 徐明 ZHANG Wenxu;XU Ming(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211100,China)
出处 《实用医学杂志》 CAS 北大核心 2019年第23期3579-3582,共4页 The Journal of Practical Medicine
基金 国家自然科学基金项目(编号:81570413,81773732)
关键词 二肽基肽酶-4 糖尿病 动脉粥样硬化 再狭窄 血管损伤 DPP-4 diabetes atherosclerosis restenosis
  • 相关文献

参考文献3

二级参考文献23

  • 1Minoru Itou,Takumi Kawaguchi,Eitaro Taniguchi,Michio Sata.Dipeptidyl peptidase-4: A key player in chronic liver disease[J].World Journal of Gastroenterology,2013,19(15):2298-2306. 被引量:25
  • 2吴学苏.糖尿病与脂肪肝[J].糖尿病之友,2007(8):50-51. 被引量:3
  • 3International Diabetes Federation (IDF). Diabetes Atlas 2013[EB/OL].[ 2014-01-30 ] .http : / / www.eatlas.idf.org / prevalence.
  • 4DEROAS G,MAFFIOLI P. Efficacy and safety profile evaluationof acarbose alone and in association with other antidiabeticdrugs: asystematic review [J].Clin Ther,2012,34(6) : 1221-1236.
  • 5XU W,BI Y,SUN Z,et al. Comparison of the effects on glycaemicontrol andp-cell function in newly diagnosed type 2 diabetespatient of treatment with exenatide, insulin or pioglitazone : amulticentr randomized parallel-group trial (the CONFIDENCEstudy) [J].J Intern Med, 2015,277( 1) : 137-150.
  • 6PONZANI P. Long-term effectiveness and safety of liraglutide inclinical [ J].Minerva Endocrinologica, 2013,38( 1) : 103-112 .
  • 7KIM YG,HAHNS,OH TJ,et al. Differences in the glucose-lowering efficacy of dipcptidyl peptidase-4 inhibitors betweenAsians and non-Asians ; a systematic review and mcta-analysis[J].Diabetologia, 2013,56(4) :696-678.
  • 8LSHIBASHI Y,NISHIN0 Y,MATSUI T,et al. Glucagon-likepeptide-1 suppresses advanced monocyteche-moattra ctantprotein-1 expression in mesangial cells by reducing advancedglycation end product receptor level [J].Metabolism, 2011,60(9):1271-1277.
  • 9SKOV J,DEJGAARD A,FR KI R J,et al. Glucagon-likepeptide-1 (GLP-1) : effect on kidney hemodynamics and renin-angiotensin-aldosterone system in healthy men [J].J ClinEndocrinol Metab,2013,98(4) :E664-E671.
  • 10EGAN AG,BLIND E,DUNDER K,et al. Pancreatic safety ofincretin-based drugs-FDA and EM A assessmenl [J].N Engl JMed, 2014,370(9):794-797.

共引文献44

同被引文献22

引证文献7

二级引证文献127

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部