摘要
目的:分析冻干重组人脑利钠肽(Rh-BNP)和硝酸甘油注射液治疗慢性心力衰竭急性失代偿(ADHF)的临床效果。方法:选择118例患者为观察对象,按随机数表法分为对照组和治疗组,各59例,常规治疗的基础上,对照组予以硝酸甘油治疗,治疗组予以Rh-BNP进行治疗。对比两组治疗效果及心功能指标NT-proBNP(N末端B型脑利钠肽)变化情况。结果:治疗组临床总有效率为95.0%,高于对照组的81.4%,差异有统计学意义(P<0.05);治疗后两组NT-proBNP水平均降低,且治疗组低于对照组,差异均有统计学意义(P<0.05)。结论:在临床治疗ADHF中,与硝酸甘油相比,冻干重组人脑利钠肽能够显著提升该病治疗总有效率,并降低NT-proBNP水平,具有良好的临床推广意义。
Objective:To analyze the clinical efficacy of lyophilized Recombinant human brain natriuretic peptide(Rh-BNP)and Nitroglycerin Injection in treatment of acute decompensated chronic heart failure(ADHF).Method:A total of 118 patients were selected as observation objects and divided into the control group and the treatment group by random number table method,59 patients in each group.On the basis of routine treatment,the control group was treated with Nitroglycerin Injection,and the treatment group was treated with Rh-BNP.The therapeutic effect and changes of cardiac function index NT-proBNP(N-terminal B-type brain natriuretic peptide)between the two groups were compared and analyzed.Result:The total clinical effective rate in the treatment group was 95.0%,which was significantly higher than 81.4%in the control group,the difference was statistically significant(P<0.05).The levels of NT-proBNP were lower in both groups after treatment,and the treatment group was lower than that in the control group(P<0.05).Conclusion:Compared with Nitroglycerin,Rh-BNP can obviously improve the total effective rate of the disease and reduce the NT-proBNP level in the treatment of ADHF,and has good clinical popularization significance.
作者
薛婉婉
XUE Wanwan(The First Affiliated Hospital of Xiamen University,Xiamen 361000,China)
出处
《中外医学研究》
2019年第34期54-56,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
