摘要
目的探讨头孢曲松钠治疗小儿细菌性肠炎的临床效果及对患儿免疫功能的影响。方法选取2017年1月至2018年12月我院收治的细菌性肠炎患儿138例,依照随机数字表平均分为常规组(n=69)和干预组(n=69),常规组行阿莫西林钠克拉维酸钾治疗,干预组行头孢曲松钠治疗。比较两组患儿治疗前、后的相关炎症因子水平、免疫功能、临床症状和体征的改善情况。结果治疗后,两组患儿的PCT、TNF-α、IL-8和CRP水平均明显低于治疗前,且干预组明显低于常规组(P<0.05)。治疗后,两组患儿的CD3+、CD4+水平明显高于治疗前,CD19+水平明显低于治疗前,且干预组优于常规组(P<0.05);治疗后,两组患儿的CD4+/CD8+明显高于治疗前(P<0.05);治疗前、后,两组患儿的CD8+水平比较,差异无统计学意义(P>0.05)。干预组患儿的发热、呕吐消失时间、脱水纠正时间、大便次数和形状恢复正常时间均明显短于常规组(P<0.05)。结论头孢曲松钠用于小儿细菌性肠炎的治疗中,可缓解患儿的炎症反应,增强其免疫功能,促进患儿临床症状和体征的缓解,效果显著,值得临床推广应用。
Objective To explore the clinical effect of ceftriaxone sodium in the treatment of children with bacterial enteritis and its effect on immune function of children.Methods A total of 138 children with bacterial enteritis admitted in our hospital from January 2017 to December 2018 were selected and averaged divided into conventional group(n=69)and intervention group(n=69)according to the random number table.The conventional group was treated with amoxicillin sodium and clavulanate potassium,while the intervention group was treated with ceftriaxone sodium.The levels of related inflammatory cytokines,immune function before and after treatment,the improvement of clinical symptoms and signs were compared between the two groups.Results After treatment,the levels of PCT,TNF-α,IL-8 and CRP in both groups were significantly lower than those before treatment,and those in the intervention group were significantly lower than the conventional group(P<0.05).After treatment,the levels of CD3+and CD4+in the two groups were significantly higher than those before treatment,while the level of CD19+was significantly lower than that before treatment,and those in the intervention group were better than the conventional group(P<0.05);after treatment,the CD4+/CD8+in the two groups was significantly higher than that before treatment(P<0.05);before and after treatment,there were no significant difference in CD8+level between the two groups(P>0.05).The disappearance time of fever and vomiting,correction time of dehydration,the time of number and shape of stool returning to normal in the intervention group were significantly shorter than those in the conventional group(P<0.05).Conclusion Ceftriaxone sodium used in the treatment of children with bacterial enteritis can alleviate the inflammatory reaction,enhance the immune function of children,and promote the relief of clinical symptoms and signs of children,with significant effect,which is worthy of clinical promotion and application.
作者
赵学敏
王红
ZHAO Xue-min;WANG Hong(the Fourth People's Hospital of Shaanxi,Xi'an 710043,China)
出处
《临床医学研究与实践》
2020年第1期101-103,共3页
Clinical Research and Practice
关键词
小儿细菌性肠炎
阿莫西林钠克拉维酸钾
头孢曲松钠
免疫功能
children with bacterial enteritis
amoxicillin sodium and clavulanate potassium
ceftriaxone sodium
immune function
