摘要
血管营养传输作用是肿瘤形成过程中不可替代的因素,阻断或降低肿瘤能量传输途径可以有效抑制肿瘤发展。JAK-STAT信号通路与血管生成之间存在密切联系,尤其是此通路与血管内皮生长因子(VEGF)信号的相关研究近几年出现了许多成果。文章综述了JAK-STAT通路的血管诱导作用、药物进展以及抗血管靶点的发现,为治疗胶质瘤提供一些思路。
Vascular nutrition transmission is an irreplaceable factor in the process of tumor formation.Blocking or reducing the energy transmission pathway of tumor can effectively resist the development of tumor.There is a close relationship between JAK-STAT signaling pathway and angiogenesis,especially research on the relationship between this pathway and vascular endothelial growth factor(VEGF)signal has produced many results in recent years.This review summarizes the induction of angiogenesis,drug development,and the discovery of antiangiogenic targets in the JAK pathway,providing some ideas for the treatment of glioma.
作者
杨鑫
段虎斌
Yang Xin;Duan Hubin(Department of Neurosurgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《肿瘤研究与临床》
CAS
2019年第11期789-792,共4页
Cancer Research and Clinic
基金
国家自然科学基金青年基金(30600637)
山西省回国留学人员重点资助项目(2016)
山西省人社厅留学基金重点项目[晋财社(201719)]。
