摘要
目的 探讨耳穴脉冲电刺激治疗胆石症 ,胆绞痛的机制 .方法 选用 15条成年杂种犬 ,进行耳穴体表脉冲刺激与缩胆素 (CCK)对在体狗胆囊张力 ,Oddi括约肌张力及肌电活动影响的对比研究 .结果 耳穴脉冲电刺激对胆囊张力无明显影响 [(1.2 7± 0 .2 6 ) k Pa与 (1.2 4± 0 .2 2 ) k Pa,P<0 .0 5 ],CCK注射液能明显提高胆囊张力 [(1.2 7± 0 .2 6 ) k Pa与 (1.91± 0 .39) k Pa,P<0 .0 5 ],CCK注射液能明显降低Oddi括约肌张力 [(2 .2 4± 0 .5 5 ) k Pa与 (1.5 8± 0 .5 6 ) k Pa,P>0 .0 5 ]及肌电活动 .结论 耳穴脉冲电刺激同 CCK一样 ,均对 Oddi括约肌的张力有显著的降低作用 ,并减少 Oddi括约肌的肌电峰电位爆发波的频率与电压值 ,推测其对胆绞痛有治疗作用 ,并有助于胆结石的排石过程 .
AIM To inspect the relationship between biliary motility dysfunction and biliary disease, the mechanism oftherapeutic effective impulsive electric stimuli of biliary colic. METHODS The dogs were amaesthetised and fixed on operating table. Abdomen wall was opened through middle line incision. When the abdomen cavity were opened, descending duodenum was incised and a catheter with water sac were inserted through Oddi sphincter orifice, another catheter inserted into gallbladder cavity, catheters were connected with two transducers respectively, then connected to polygraphy system. A set of record electrode were inserted in Oddi sphincter, then connected with polygraphy system. The dogs were managed with impulsive electric stimuli and CCK injection. RESULTS ①Impulsive electric stimulation had no significant effect on gallbladder tension; ②CCK injection increased the gallbladder cavity pressure significantly; ③CCK injection decreased the pressure of oddi sphincter and its myoelectric activity; ④Impulsive electric stimuli decreased the pressure of oddi sphincter. CONCLUSION Electric stimuli and CCK injection can decrease the oddi sphincter pressure and myoelectric activity significantly. Thus the electric stimuli have a therapeutic effect on biliary colic.
出处
《第四军医大学学报》
CAS
北大核心
2002年第21期1926-1928,共3页
Journal of the Fourth Military Medical University
