摘要
目的 探讨早期改善胰腺微循环对治疗重症急性胰腺炎 (SAP)的疗效。方法 回顾性分析对比 1995～ 1998年 44例 (前期 )和 1998～ 2 0 0 1年 40例 (后期 )SAP患者的治疗效果。前期采取常规统一治疗 ,后期增加改善胰腺缺血及防止细胞钙超负荷的措施。结果 后期患者治愈率(85 .0 % )显著高于前期SAP患者治愈率 (68.2 % ) (P <0 .0 5 ) ;后期死亡率 (15 .0 % )、中转手术率(2 2 .5 % )、并发症率 (3 5 .0 % )明显地低于前期 (3 1.8%、40 .9%、5 4.5 % ) (P <0 .0 5 )。后期平均住院日 (2 2± 4)d ,较前期平均住院日 (3 2± 7)d明显缩短 (P <0 .0 5 )。结论 改善胰腺缺血和防止细胞钙超负荷有助于限制SAP恶化进程 。
Objective To evaluate the effect of ameliorating the pancreatic microcirculation in the early stage on the patients with severe acute pancreatitis(SAP). Methods 84 SAP patients admitted from 1995-1998 and 1998-2001 were retrospectively analyzed. Routine united management were given to 44 SAP patients in the former period (FP)(1995-1998),and special regime aimed at improving the microcirculation and preventing cell Ca 2+ overload besides routine management were given to 40 SAP patients in the later period(LP)(1998-2001).Results Cure rate (85.0%) in FP group was significantly higher than that of LP group(68.2%)(P<0.05);the mortality (15.0%)?the rate of late operation(22.5%)?the rate of complications in LP group(35.0%) were significantly lower than those in FP group (31.8%,40.9%,54.5%)(P<0.05).The average time stayed in hospital in LP group(22±4)d was significantly shorter than that of FP group (32±7)d (P<0.05).Conclusion Ameliorating pancreatic microcirculation and preventing pancreatic cell Ca 2+ overload can restrict SAP from worsening and improve the prognosis of SAP.
出处
《临床外科杂志》
2002年第6期337-338,共2页
Journal of Clinical Surgery
