摘要
目的 观察慢性肝病患者肝功能中的A/G比值、ALT/AST比值、透明质酸 (HA)、门静脉 (PV)直径和脾厚经与肝组织纤维化程度的关系 ,探讨无创性指标对肝纤维化程度的预测价值。方法 对 72例慢性乙肝患者肝活检确定纤维化分期。治疗前测定血清A/G比值、ALT/AST比值 ,HA ,B超测定PV直径和脾厚径。结果 伴随肝组织纤维程度增加 ,A/G比值、ALT/AST比值呈下降趋势 ,但仅纤维化 4期 (S4)与 1期 (S1)比较 ,差异有显著性。HA在纤维化不同期检测水平随炎症及纤维化进展逐渐升高 ,尤以S3 、S4明显升高。PV直径 (mm)和脾厚径 (cm)在早期就随纤维化程度增加而升高 ,S2 、S3 、S4与S1比较 ,差异无有显著性。结论 血清A/G比值、ALT/AST比值、HA。
AIM\ To observe the relation of A/G ratio, ALT/AST ratio, HA, diameter of portal vein(PV) and thickness of spleen with the degree of fibrosis of liver. To probe the worth of prognose of degree of fibrosis of liver with non invasive examination. METHODS\ Stages of fibrosis of 72 patients with chronic virus B hepatitis were confired with hepatoscopy, A/G ration, ALT/AST ratio, HA were assayed befored therapy and diameter of PV thickness of spleen were confired with B us. RESULTS\ A/G ratio, ALT/ASTratio apperated degressive diraction with increase of fibrosis. Only the Ⅳ stage(S 4) and Ⅰ stage(S 1) had significant difference. The lever of HA in different stages of fibrosis increased gradually with progress of phlogosis and fibrosis, especially for S 3,S 4 level. Diameter of PV thickness of spleen increased with the progress of degree of fibrosis in early. Compaired with S 2, S3, S 4, there were significant difference. CONSLUSION\ It was valuable for assessment midding to serious fibrosis of liver with A/G ratio, ALT/AST ratio, HA, diameter of portal vein(PV) and thickness of spleen.
出处
《安徽医药》
CAS
2002年第4期37-39,共3页
Anhui Medical and Pharmaceutical Journal
关键词
肝纤维化
血清酶
超声检查
慢性肝病
肝功能
fibrosis of lier
serumal enzyme
examination of B us
chronic hepatism
