摘要
对慢迁肝、慢活肝、肝炎后肝硬化、日本血吸虫病早期和晚期患者共612例(其中157例经肝活检确诊)进行血清ADA、CG、β_2-M、NAG、GST、HyP、PIP、HA、LN、TNF-α、sIL-2R等11项指标的检测.检测结果用阳性(>(?)+2SD)率表示,大致与肝组织学检查结果相似,肝纤维化程度早血、迁肝<晚血<慢活肝<肝炎后肝硬化,而肝脏炎症、坏死则以慢活肝为重.我们认为肝纤维化的诊断应综合考虑.本文从反映慢性肝受损指标、细胞外间质代谢指标及细胞因子网络失调指标3方面,初步提出肝纤维化血清学诊断指标谱,供讨论。
612 patients with chronic liver diseases,including chronic persisting hepatitis,chronic active hepatitis, posthepatitic cirrhosis, schistosomiasis japonica were detected by the methods of serodiagnosis which are ADA, CG, β2-M, NAG, GST, HYP, PⅢP, HA, LN, TNF-α and sIL-2R,The results of serological test were indicated by positive rate(>X+2SD) and same as the results of hepatic histological examination. The order of degree of seriousness of hepatic fibrosis are early stage of schistosomiasis japonica and chronic persisting hepatitis< advanced stage of schistosomiasis japonica<chronic active hepatitis<posthepatitc cirrhosis. The seriousest disease in hepatic inflammation and necrosis is chronic active hepatitis. The authors believe that in order to make a diagnosis of hepatic fibrosis must synthesize the results of determination and the index spectrum of serodiagnosis must include following three parts: 1. can reflect hepatic chronic damage, 2. can reflect the metabolism of the extracellular matrix, 3. can reflect the disorder of network of cell factor.
出处
《中西医结合肝病杂志》
CAS
1995年第1期3-6,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
肝纤维化
血清学诊断
慢性肝病
Hepatic Fibrosis Serodiagnosis Chronic Liver Diseases
