摘要
目的 探索内蒙籍蒙古族儿童HLA DRB1等位基因对过敏性紫癜 (AP)的遗传易感性。方法 采用PCR SSP技术 ,在祖籍三代居住内蒙地区蒙古族人群中 ,选择 5 7例儿童AP和 10 2例健康儿童 ,作以HLA DRB1等位基因的型别分析。结果 病例组DRB1 110x等位基因频率为 13 2 % ,明显高于对照组6 1% ,差异有显著意义 (χ2 =4 378,P =0 0 36 <0 0 5 )。并得出RR =2 386 >1,其 95 %可信区间为 1 0 4 5～5 4 4 7,其内不包含 1,与P值意义相符 ,既有统计学意义 ,又有实际意义。EF =0 14 3>0。结论 HLA DRB1 110x等位基因可能是内蒙籍蒙古族儿童AP发病单体型中一个遗传易感基因。
Objective To analysis the genetic susceptibility of HLA DRB1 allele to anaphylactoid purpura in juvenile Mongolia inhabited in inner Mongolia.Methods In Mongolia residing in inner Mongolia,which were traced back to those having not consanguinity,history of mixed marriages,other medical history and family history of rheumatic disease.57 juvenile with AP and 102 normal juvenile controls were tested for HLA DRB1 allelic types analysis by PCR SSP technique.Results Gene frequence of HLA DRB1*110x in AP group(13.2%) was significantly higher than that of control group(6.1%),and difference had statistical significance(χ 2=4.378,P=0.036<0.05).RR=2.386>1,95% confidence interval:1.045～5.447,which did not include 1.The significance correponded to the relevant value of P,which is significant both in statistics and realilies.EF=0.143>0.Conclusion The allele of HLA DRB1*110x probably was the susceptible gene of the juvenile with AP.
出处
《中国基层医药》
CAS
2002年第11期964-965,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
内蒙古自治区科委自然科学基金 (编号 :990 3 0 2 1)
