摘要
Objective: To evaluate the interaction between serum levels of soluble intercellular adhesion molecule 1 (sICAM 1) and Helicobacter pylori (H. pylori) infection in patients with chronic gastritis and peptic ulcer. Methods: The serum levels of sICAM 1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H. pylori was determined by histologic examination, RUT, 14 C UBT, and serology. The sera obtained from 18 healthy volunteers served as controls. Results: The serum levels of sICAM 1 were significantly higher in patients with H. pylori positive than those of H. pylori negative (889.43±32.52 ng/ml vs. 747.07±30.45 ng/ml, P <0.05). The serum levels of sICAM 1 in patients with mild, moderate and severe infection of H. pylori were 841.68±72.36 ng/ml, 905.43±37.59 ng/ml and 1012.54±49.34 ng/ml,respectively ( P <0.05). The serum levels of sICAM 1 proved to be significantly correlated with the density of H. pylori colonization in gastric mucosa ( r s =0.316, P < 0.001) . The serum levels of sICAM 1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls ( P <0.05). Conclusions: These results indicated that H. pylori infection up regulates the expression of sICAM 1.
Objective:To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1(sICAM-1) and Helicobacter pylori(H.pylori) infection in patients with chronic gastritis and peptic ulcer.Methods:The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H.pylori was determined by histologic examination.RUT,^14C=UBT,and serology,Ther sera obtained from 18 healthy volunteers served as controls,Results:The serum lervels of sICAM-1 were significantly higher in patients with H.pylori positive than those of H.pylori negative(889.43±32.52ng/mlvs,747.07±30.45ng/ml,P<0.05),The serum levels of sICAM-1 in patients with mild,moderate and severe infection of H.pylori were 841.68±72.36ng/ml,905.43±37.59ng/ml and 1012.54±49.34ng/ml,respectively(P<0.05),The serum levels of sICAM-1 proved to be significantly correlated with the density of H.pylori colonization in gastric mucosa(rs=0.316,P<0.001),The serum levels of sICAM-1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls(P<0.05).Conclusions:These results indicated that H.pylori infection up-regulates the expression of sICAM-1.
