摘要
目的:观察糖尿病大鼠血浆中CGRP的含量变化与24h尿微量白蛋白的关系,为早期防治DN提供理论依据.方法:Wi sta r大鼠.体重160～200g,于造成糖尿病大鼠模型后第6,8、10.1 2、14周测定血浆中的CGRP和24h尿微量白蛋白.结果:血浆中的CGRP在造模后第6周无明显改变,第8周开始呈进行性下降,并与24h尿微量白蛋白呈显著负相关.结论:动态观察血浆中CGRP的变化对于DN的早期发现及分析病情有重要意义.
Objective: To provide theoretical basis for preventing early injury of kidney, we observed the relationship between the alteration in serum CGRP in diabetic rats and the quantity of uric micro-albumin in 24h. Methods: Wistar rats, weight 160~200g, were assayed for the serum CGRP content in diabetic rats and the quantity of uric micro-albumin in 24h at the 6th,8th,10th,12th and 14th weeks after they were made the model of diabetic rats. Results: The CGRP content in serum in diabetic rats did not obviously alter at the 6th week but it evidently declined at the 8th week and related with the quantity of uric micro-albumin in 24h. Conclusion: The alteration in serum CGRP in diabetic rats is significant in early discovering and analyzing DN.
出处
《黑龙江医药科学》
2002年第5期20-20,共1页
Heilongjiang Medicine and Pharmacy
