摘要
用微量分光光度法对正常人、肝细胞癌(HCC)、良性肝病和其它疾病患者血清α—L-岩藻糖苷酶(SAFU)的活性进行了测定。结果表明,HCC患者SAFU活性(765.10±289.00nmol/ml·h) 明显高于正常人(409.33±83.95nmol/ml·h),67.80％的HCC患者SAFU活性高于正常值上限,而且与血清甲胎蛋白(AFP)无关。虽然相当一部分肝炎和肝硬化患者SAFU也增高,但这些病人往往伴有明显的肝功能异常。提示:SAFU活性可作为HCC的又一诊断指标。
The activity of serum a -L-fucosidase (SAFU) in normal subjects and patients with hepatocellular carcinoma(HCC), benign liver diseases as well as other disaeses were determined by the microquantitative spectrophotometry. The results showed that SAFU activity in patients with HCC(765.10±289.00 nmol/ml·h ) was obviously higher than that in normal subjects(409.33±83.95 nmol/ml·h). SAFU activity increased over the upper line of the normal value in 67.80%of HCC patients, which had no relationship with serum α - fetoprotein. Although some patients with hepatitis and liver cirrhosis also had a elevated SAFU activity they were usually accompanied by the appearant abnormality in their liver functions. It is suggested that SAFU activity might be used as an index in the diagnosis of HCC.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1992年第2期100-103,共4页
Chinese Journal of Cancer
关键词
细胞癌
岩藻糖
苷酶
血清
肝肿瘤
hepatocellular carcinoma fucosidase serum diagnosis
