摘要
测定了原发性肝癌７７例（ＰＨＣ组），肝硬化３５例（ＤＣ组），消化系统其他恶性肿瘤患者３３例（ＤＳＣ组）及健康人１００例（ＮＣ组）血清α－Ｌ－岩藻糖苷酶（ＡＦＵ）活力。结果表明：ＰＨＣ组ＡＦＵ（６６９．６±１９１．５ｎｍｏｌ·ｍｌ￣（－１）·ｈ￣（－１））显著高于ＮＣ组（３１４．３±６７．０ｎｍｏｌ·ｍｌ￣（－１）·ｈ￣（－１），Ｐ＜０．０１），ＤＳＣ组（３９０．６±１０２．３ｎｍｏｌ·ｍｌ￣（－１）·ｈ￣（－１），Ｐ＜０．０１）和ＤＣ组（４５８．３±１５０．１ｎｍｏｌ·ｍｌ￣（－１）·ｈ￣（－１），Ｐ＜０．０５）。其诊断敏感性和特异性分别为７１．４％和８９．３％，与ＡＦＰ联合检测时ＰＨＣ组总的阳性检出率达８８．２％。
erum α-L-fucosidase(AFU)was determined in 77 cases of pfimary hepatic carcinoma(PHC),35 cases of decompensated cirrhosis(DC),33 cases of other digestive system carcinoma(DSC)and 100 cases of normal contrl(NC).The results showed that the value of AFU activityin PHC group(669.6±l91.5nmol·m-1·h-1) was hihger than that in DSC group(390.6±102.3 nmol·m-1·h-1),NC group(314.3±67.0nmol·m-1·h-1)and DC group(458.3±150.1nmol· ml-1·h-1)(P<0.01).When the normal value of AFU activitv was>600nmol·ml-1·h-1,the sensitivity and specificity were 71.4%and 89.3%,respectively.The total posi-tive rate was 88.2%in AFU combination with AFP examination in patients with PHC,whichwas higher than the positive rate of AFU or AFP determined separately.
出处
《湖南医科大学学报》
CSCD
1996年第4期349-351,共3页
Bulletin of Hunan Medical University
关键词
岩藻糖苷酶
肝肿瘤
甲胎蛋白
诊断
α-L-fucosidase
liver neoplasms
carcinoma
alpha fetoproteins
diagnos-tic use
