摘要
本文报告用致突变和抗突变同步试验法对中药苦杏仁的测试结果,发现其无致突变性,而且对表阿霉素、卡铂、环己亚硝脲、甲基苄肼、塞替哌、呋喃氟脲嘧啶、丝裂霉素C(MMC)、平阳霉素、氟脲嘧啶、顺铂、阿糖胞苷、盐酸氮芥12种抗肿瘤药物的诱变性有明显的抑制作用,经原噬菌体诱导及Ames两种同步试验法,加及不加大鼠微粒体酶代谢活化系统(S_9),结果一致,提示苦杏仁可望成为肿瘤化疗药物毒副作用的拮抗剂。
With the aim to see whether Almod has the function of inhibiting genetic toxicity, we adopted rnutational and antimutational synchronous inductest and Ames' test to examine it's reaction towards mutagenesis induced by 12 antineoplastic drugs .The results indicated that Almond suppresses mutagenesis induced by Fluo-rouracilum, Ftorafurum,Cytarabinum, Mitomycinum Procarbazinum, Cis. platinum diamine dichloridum, Thiophosphoramide, Lomustinum, Mustinae hydrochloridum, Pharmorubicin, Carboplatinum and Bleomycunum.It Seemed that Almond can be prescribed to clinical cancer patients while receiving chemotherapy to eliminate the drug's side genotoxicity.
出处
《癌变·畸变·突变》
CAS
CSCD
1992年第6期49-50,10,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
苦杏仁
抗突变
抗癌药
Almond
Antineoplastic drugs
Antimutagenesis
