摘要
本试验以环磷酰胺为阳性药，以嗜多染红细胞微核率为指标探索板兰根、鱼腥草、女贞子和枸杞子保护正常分裂细胞染色体，降低化疗中毒副作用骨髓抑制的作用机理，揭示此４种药均有抗环磷酰胺引起的嗜多染红细胞微核率升高作用，且用药量与疗效间有一定量效关系．此４种中药在临床上可用于降低化疗引起的毒副作用和日常生活中保护正常分裂细胞不受诱变剂影响的抗变保健作用。
This experiment used micronucleus(MN) of mice as a marker test the action ofIsatis tinctorza,Houttuynia cordata,Lycium barbarum and Ligustrum lucidum on arrest of bonemarrow by cyclophosphomidum(CP).The results showed that the 4 kinds of Chinesemedicines can reduce the MN rate of polychromatic erythracytes by CP and have mutation re-sistance. And they showed notable dose-effect relationship. [
出处
《北京联合大学学报》
CAS
1994年第1期58-61,共4页
Journal of Beijing Union University
关键词
环磷酰胺
抗癌药
中药
骨髓抑制
cyclophosphomidum
MN rate
mutation resistance
dose-effect relationship.
