摘要
目的探讨检测尿蛋白/肌酐(Up/Cr)、24h尿蛋白(24hUp)及肾功能检测在慢性肾病诊断中的价值。方法选取2017年9月~2018年12月我院收治的慢性肾病患者526例,根据肌酐清除率(Ccr)分为肾功能正常组100例、轻度损害组105例、中度损害组105例、重度损害组108例和尿毒症组108例。比较五组血肌酐(Scr)、Up/Cr、24hUp水平,并分析Up/Cr和24hUp的相关性。结果中度、重度损害组和尿毒症组Scr高于肾功能正常组和轻度损害组,差异有统计学意义(P<0.05);肾功能正常组和轻度损害组Scr比较,差异无统计学意义(P>0.05)。轻度、中度、重度损害组、尿毒症组Up/Cr高于肾功能正常组,轻度、中度、重度损害组、尿毒症组24hUp高于肾功能正常组,差异有统计学意义(P<0.05)。肾功能正常组、轻度损害组、中度损害组和重度损害组Up/Cr和24hUp有相关性(P<0.05);尿毒症组Up/Cr和24hUp无相关性(P>0.05)。结论UP/Cr和24hUP早期诊断慢性肾病效果优于Scr,当Ccr超过了10ml/min时,其可用于临床慢性肾病的早期筛检。
Objective To investigate the value of urine protein/creatinine(Up/Cr),24h urine protein(24h Up)and renal function test in the diagnosis of chronic kidney disease.Methods A total of 526 patients with chronic kidney disease admitted to our hospital from September 2017 to December 2018 were enrolled.According to creatinine clearance rate(Ccr),there were 100 patients with normal renal function,105 patients with mild injury,and 105 patients with moderate damage.108 patients in the severe injury group and 108 patients in the uremic group.5 groups of serum creatinine(Scr),Up/Cr,and 24h Up levels were compared,and the correlation between Up/Cr and 24h Up was analyzed.Results The Scr of the moderate,severe injury group and uremic group was higher than that of the normal renal function group and the mild damage group(P<0.05).There was no significant difference in the Scr between the normal renal function group and the mild injury group(P>0.05).In the mild,moderate,severe lesion groups and the uremia group,the Up/Cr group was higher than the normal renal function group;mild,moderate,severe injury groups,uremia group 24h Up was higher than normal renal function group,the highest in the moderate damage group,the difference was statistically significant(P<0.05).There was a correlation between Up/Cr and 24h Up in the normal renal function group,mild,moderate group and the severe damage groups(P<0.05).There was no correlation between Up/Cr and 24h Up in the uremic group(P>0.05).Conclusion The early diagnosis of chronic kidney disease by UP/Cr and 24h UP is better than Scr.When Ccr exceeds 10 ml/min,it can be used for early screening of clinical chronic kidney disease.
作者
陈吉虎
CHEN Ji-hu(Department of Clinical Laboratory,Tianjin Wuqing District Traditional Chinese MedicineHospital,Tianjin 301700,China)
出处
《医学信息》
2019年第17期174-175,共2页
Journal of Medical Information
关键词
尿蛋白/肌酐
24h尿蛋白
慢性肾病
肾功能
Urinary protein/creatinine
24h urine protein
Chronic kidney disease
Renal function
