摘要
目的观察丹参注射液联合非布司他治疗慢性尿酸性肾病的临床疗效和安全性。方法将2016年1月—2017年4月浙江中医药大学附属温州中医院肾内科收治的94例慢性尿酸性肾病患者按随机数字表法分为对照组和试验组,每组47例。对照组给予非布司他40 mg,1次/d,口服;观察组给予丹参注射液30 ml,1次/d,静滴+非布司他40 mg,1次/d,口服。8周后观察2组患者的临床疗效和药物不良反应发生情况,比较2组肾功能、血脂和性激素指标水平。结果试验组总有效率为91. 49%,显著高于对照组的70. 21%(P <0. 05)。试验组的肌酐(Scr)、尿素氮(BUN)、尿酸(UA)、24小时尿蛋白定量、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、雌二醇(E2)和睾酮(T)显著低于对照组,而肾小球滤过率(e GFR)和高密度脂蛋白(HDL)水平显著高于对照组(P <0. 05)。试验组和对照组泌乳素(PRL)水平比较差异无统计学意义(P> 0. 05)。药物不良反应主要为肝功能异常、恶心、关节痛、皮疹等,试验组和对照组的药物不良反应发生率分别为12. 77%和8. 51%(P> 0. 05)。结论丹参注射液联合非布司他治疗慢性尿酸性肾病具有较好的疗效,可保护肾功能,改善血脂指标和性激素水平,且安全性较好。
Objective To observe the curative effect and safety of danshen injection combined with febuxostat in the treatment of patients with chronic uric acid nephropathy. Methods Ninety-four patients with chronic uric acid nephropathy were randomly divided into control group and treatment group with forty-seven cases per group. The control group was given febuxostat 40 mg, qd, po, and the treatment group was given danshen injection 30 ml, qd, ivgtt ＋ febuxostat 40 mg, qd, po. After 8 weeks treatment, the clinical efficacy and occurrence of adverse drug reactions were observed. The levels of renal function, blood lipids and sex hormones were compared. Results The total effective rate 91.49% in treatment group was higher than the control group （ P 〈 0.05 ）. The levels of serum creatinine （ Scr）, blood urea nitrogen （BUN）, uric acid （UA）, 24 h urine protein （UPRO）, triglyceride （TG）, total cholesterol （TC）, low-density lipopro- tein （LDL）, estradiol （E2） and testosterone （T） in treatment group were lower than the control group, and the levels of glomerular filtration rate （eGFR） and high-density lipoprotein （HDL） were higher than the control group （P 〈 0. 05 ）. The levels of prolactin （PRL） in treatment group and control group was no significant （P 〉0.05）. The adverse drug reactions were mainly abnormal liver function, nausea, joint pain and rashes, the incidence of adverse drug reactions in treatment group and control group were 12.77% and 8.51%, respectively （P 〉 0. 05 ）. Conclusion The danshen injection combined with febuxostat in the treatment of chronic uric acid nephropathy have significantly curative effect, can protect renal function, improve the blood lipid index and sex hormone levels, and have no increasing the adverse drug reactions.
作者
邵思思
黄蔚霞
项协隆
冯如流
陈春
胡振奋
SHAO Si-si;HUANG Wei-xia;XIANG Xie-long(Department of Nephrology,the Affiliated Wenzhou Traditional Chinese Hospital of Zhejiang Traditional Chinese Medicine University,Wenzhou,Zhejiang 325000,China)
出处
《中华全科医学》
2018年第11期1843-1846,共4页
Chinese Journal of General Practice
基金
浙江省中医药科技计划项目(2015ZA198)
浙江省温州市科技计划局项目(Y20160212)
关键词
丹参注射液
非布司他
尿酸性肾病
肾功能
性激素
Danshen injection
Febuxostat
Uric acid nephropathy
Renal function
Sex hormones
