摘要
目的探讨尿蛋白/肌酐、24 h尿蛋白及肾功能指标检测在慢性肾病诊断中的临床价值。方法方便选取2016年12月—2018年2月该院收治的慢性肾病患者86例作为该研究对象,根据肾功能情况将其随机分为两组,各43例,肾功能正常者为对照组;肾功能异常者为研究组,两组患者均采用同一检测法进行检测。对比两组患者肾功能的各项检测结果。结果检测前对照组的血清肌酐为(938.48±127.36)μmol/L,尿素氮为(48.39±11.63)mmol/L以及内生肌酐为(11.35±6.30)mL/min,且研究组的血清肌酐为(940.33±134.53)μmol/L,尿素氮为(47.97±10.53)mmol/L以及内生肌酐为(10.91±5.56)mL/min,两组差异无统计学意义(t=1.635、1.226、1.658,P>0.05),检测后研究组的血清肌酐为(243.82±61.74)μmol/L、尿素氮为(16.14±8.36)mmol/L,而对照组血清肌酐为(423.61±92.35μmol/L、尿素氮为(22.37±8.15)mmol/L,研究组低于对照组(t=18.943、17.225,P<0.05),且内生肌酐为(24.35±11.02)mL/min高于对照组的(15.38±8.2)mL/min(t=17.325,P<0.05);研究组Up/Ucr为(52.34±86.53)及24 hUp为(3.25±3.75)g/24 h均显著高于对照组的Up/Ucr(40.89±57.53)与(2.89±3.51)g/24 h(t=16.334、15.391,P=0.01)。结论在慢性肾病诊断过程中, UP/Cr比值能取代24 hUP定量作为检测慢性肾病的关键指标;且与肾功能无相关性,筛查效果良好,临床上应进一步推广应用。
Objective To investigate the clinical value of urine protein/creatinine, 24h urine protein and renal function test in the diagnosis of chronic kidney disease. Methods Eighty-six patients with chronic kidney disease admitted to the hospital from December 2016 to February 2018 were convenient enrolled in this study. They were randomly divided into two groups according to renal function, 43 cases in each group, and those with normal renal function were the control group; Those with abnormal function were the study group, and both groups were tested by the same test method. The results of various renal function tests were compared between the two groups. Results The serum creatinine of the control group was （938.48±127.36）μmol/L, the urea nitrogen was （48.39±11.63）mmol/L, and the endogenous creatinine was （11.35±6.30）mL/min. The serum creatinine of the study group was （940.33±134.53）μmol/L. The urea nitrogen was （47.97±10.53）mmol/L and the endogenous creatinine was（ 10.91±5.56）mL/min. There was no significant difference between the two groups （t=1.635, 1.226, 1.658, P〉0.05）. The serum creatinine was （244.82±61.74）μmol/L, and the urea nitrogen was （16.14±8.36）mmol/L. The serum creatinine of the control group was （423.61±92.35）μmol/L, and the urea nitrogen was （22.37±8.15）mmol/L. The study group was lower than the control group （t=18.943, 17.225, P〈0.05）, and endogenous creatinine was （24.35±11.02）mL/min higher than the control group of （15.38±8.2）mL/min （t=17.325, P〈0.05）; Up/Ucr were （52.34±86.53） and 24 hUp were （3.25±3.75）g/ 24 h, which were significantly higher than the control group＇s Up/Ucr（40.89±57.53） and （2.89±3.51）g/24 h（t=16.334, 15.391, P=0.01）. Conclusion In the diagnosis of chronic kidney disease, UP/Cr ratio can replace 24 hUP quantitative as a key indicator for detecting chronic kidney disease; and it has no correlation with renal function, and the screening effect is satisfatm7. It should be further promoted and applied clinically.
作者
胡君
王春
HU Jun;WANG Chun(Department of Clinical Laboratory,Friendship Hospital,Urumqi,Xinjiang,830000 China)
出处
《中外医疗》
2018年第27期180-182,共3页
China & Foreign Medical Treatment
关键词
尿蛋白/肌酐
24
h尿蛋白
肾功能指标
检测
慢性肾病
临床
价值
Urine protein / creatinine
24 h urine protein
Renal function indicators
Detection
Chronic kidney disease
Clinical
Value
