摘要
目的探讨氢溴酸樟柳碱注射液治疗急性缺血性脑卒中患者的疗效和安全性。方法纳入122例缺血性脑卒中患者,所有患者均因治疗时间窗问题未使用溶栓治疗,均接受基础治疗及氢溴酸樟柳碱注射液治疗。治疗1周及2周后,对患者进行改良Rankin量表(mRS)及美国国立卫生研究院卒中量表(NIHSS)评分,并计算治疗有效率。结果患者的NIHSS和mRS评分均有随时间延长而降低的趋势(均P<0.05)。治疗1、2周后,治疗有效率分别为52.46%、82.79%,治疗2周后的有效率高于治疗1周后(P<0.05)。共15例患者出现潮红、口干,未经干预自行消失,未出现心血管不良事件及其他不良反应。结论在基础治疗的基础上,氢溴酸樟柳碱注射液治疗对缺血性脑卒中患者具有较好的疗效,安全性佳。
Objective To explore the efficacy and safety of Anisodine Hydrobromide Injection in the treatment of patients with acute ischemic stroke. Methods A total of 122 patients with acute ischemic stroke were enrolled,and did not receive thrombolytic therapy due to the therapeutic time window.All of the patients received basic treatment,and were also administered Anisodine Hydrobromide Injection.After 1 and 2 weeks of treatment,the assessment using the modified Rankin Scale(mRS) and the National Institutes of Health Stroke Scale(NIHSS) was conducted in all patients ,and the effective rate was calculated. Results The NIHSS score and mRS score of the patients decreased with the increase of the time(all P <0.05).The effective rates at 1 and 2 weeks after treatment were 52.46% and 82.79%,respectively,and the rate at 2 weeks after treatment was higher than that at 1 week after treatment( P <0.05).Skin flush and dry mouth occurred in 15 cases,and disappeared without intervention,no adverse cardiovascular events or other adverse reactions occurred. Conclusion On the basis of basic treatment,Anisodine Hydrobromide Injection can obtain a better efficacy and good safety for treating acute ischemic stroke.
作者
刘春刚
冼文川
罗宋宝
钟强
翁国媚
张洁茵
李莉
LIU Chun-gang;XIAN Wen-chuan;LUO Song-bao;ZHONG Qiang;WENG Guo-mei;ZHANG Jie-yin;LI Li(Department of Acupuncture and Rehabilitation,Xindu Hospital of Traditional Chinese Medicine,Chengdu 610599,China;Department of Neurology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China;Department of Neurology, the First People′s Hospital of Zhaoqing,Zhaoqing 526000,China;Department of Neurology,Sichuan Integrative Medicine Hospital,Chengdu 610041,China;Department of Clinical Teaching,Chengdu Railway Health School,Chengdu 611741,China)
出处
《广西医学》
CAS
2019年第14期1742-1744,1748,共4页
Guangxi Medical Journal
基金
四川省科技计划项目(2016SZ0027、2015SZ0018)
