摘要
目的基于网络药理学,研究新疆罗勒挥发油活性成分。方法从不同开源数据库中收集罗勒挥发油的活性成分,预测和筛选出活性成分的作用靶点及其作用的信号通路,构建成分-靶点-通路网络来阐明罗勒挥发油成分对疾病的作用机制。结果筛选出了6个罗勒挥发油活性成分,经成分-靶点-通路网络的分析,发现有25个主要的作用靶点和5个主要的作用通路。结论罗勒挥发油活性成分主要通过5个信号通路作用于皮肤病、癌症、心脑血管疾病等。
Aim To study the active ingredients of essential oil in Xinjiang Ocimum basilicum L.based on system network pharmacology. Methods Information on the active ingredients of essential oil in Ocimum basilicum L.was collected from different open source databases.The functional targets together with their signaling pathway were predicted and screened.The ingredients,target proteins and their signaling pathways were established to illustrate the functional mechanism of active ingredients of essential oil in Ocimum basilicum L.against the diseases. Results Six active components of basil volatile oil were identified by analyzing the network of ingredient,target and pathway.Twenty-five main functional targets with five major pathways were also recognized. Conclusions The active components of basil essential oil mainly exert their effects on skin diseases,cancer and cardiovascular and cerebrovascular diseases through five signaling pathways.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第5期701-706,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81560586)
新疆维吾尔自治区自然科学基金资助项目(No 2016D01C161)
新疆医科大学研究生创新创业启动基金项目(No CXCY2018007)
新疆医科大学博士后科研启动基金项目
新疆自治区"十三五"重点学科建设项目
关键词
网络药理学
罗勒
挥发油
天然药物
有效成分
作用靶点
network pharmacology
Ocimum basilicum L.
volatile oil
natural medicine
active ingredient
target
