摘要
1例1岁女性患儿,首次静脉滴注磷酸肌酸钠即出现呼吸急促、全身及四肢发抖、面色潮红和口唇发绀;立即停止输注磷酸肌酸钠,予以吸氧、地塞米松静脉注射、0.9%氯化钠注射液静脉滴注、小儿退热栓塞肛和心电监护,8.5 h后体温恢复正常。该患儿在使用磷酸肌酸钠的过程中无其他联合用药,发病迅速,所用的同批次溶剂无该类药品不良反应,故判断该ADR与静脉滴注磷酸肌酸钠存在因果关系。磷酸肌酸可能引起过敏性紫绀,出现该现象时应立刻停止给药,并进行对症治疗。
In one 1-year-old female patient, the first intravenous infusion of sodium phosphocreatine resulted in shortness of breath, trembling of the whole body and limbs, flushed complexion and cyanosis of the lips. The infusion of sodium creatine phosphate was immediately stopped, and the intravenous oxygen, dexamethasone intravenous injection, 0.9% sodium chloride injection intravenous infusion, pediatric antipyretic embolization anus and ECG monitoring were given, the body temperature of the patient returned to the normal state after 8.5 h. In the process of using sodium phosphocreatine, the child had no other combined medication, and the onset was rapid. The same batch of solvent used did not have adverse dug reactions(ADR) of the drugs, so it was judged that there was a causal relationship between the ADR and the intravenous infusion of sodium creatine phosphate. Phosphocreatine may induce anaphylactic cyanosis, the drugs should be stopped immediately and symptomatic treatment should be performed.
作者
卢金淼
李琴
李智平
LU Jinmiao;LI Qin;LI Zhiping(Dept.of Clinical Pharmacy,Children’s Hospital of Fudan University,Shanghai 201102,China)
出处
《中国医院用药评价与分析》
2019年第3期381-381,383,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
"中国-世界卫生组织2016-2017双年度合作项目"儿童用药安全性和可及性相关因素对策研究"(No.2016/647672-0)
上海市卫生计生系统薄弱学科建设项目(No.2016ZB0305)
