摘要
目的分析细菌性阴道病和阴道微生态改变与高危型人乳头瘤病毒(HR-HPV)感染的关系。方法回顾性分析2016年7~12月在上海交通大学医学院附属国际和平妇幼保健院宫颈专病诊治中心进行阴道分泌物HRHPV筛查的1768名女性的临床资料。1768例女性分为HR-HPV阳性组和阴性组,比较两组女性中阴道微生态相关指标(p H值、唾液酸苷酶、过氧化氢和白细胞酯酶)和细菌性阴道病的发生情况。结果 1768例研究对象中,HR-HPV阳性组527例(29.80%),HR-HPV阴性组1241例(70.20%)。细菌性阴道病共114例(6.44%),其中HRHPV阳性组中细菌性阴道病的构成比为11.57%,HR-HPV阴性组中细菌性阴道病的构成比为4.27%,两组细菌性阴道病的构成比比较,差异有统计学意义(P<0.05)。微生态四项指标均阳性者(p H>4.5,唾液酸苷酶阳性、过氧化氢阳性、白细胞酯酶阳性)98例(5.54%),其中HR-HPV阳性组中微生态四项指标均阳性者的构成比为8.54%,HR-HPV阴性组中微生态四项指标均阳性者的构成比为4.27%,阴道微生态四项指标均阳性者的构成比在两组中比较,差异有统计学意义(P<0.05)。结论细菌性阴道病和阴道微生态改变与HR-HPV感染密切相关。减少细菌性阴道病的发生,维护阴道微生态平衡,可以降低HR-HPV的感染率。
Objective To analyze the relationship between bacterial vaginosis(BV)and vaginal microecological changes with high risk human papillomavirus(HR-HPV)infection.Methods The clinical data of 1768 female vaginal secretions screened by HR-HPV from July to December 2016 were analyzed retrospectively.1768 women were divided into HR-HPV positive group and negative group.Vaginal microecological indicators(pH,sialidase,hydrogen peroxide and leukocyte esterase)and bacterial vaginosis were compared between the two groups.Results Among 1768 subjects,527(29.80%)were HR-HPV positive and 1241(70.20%)were HR-HPV negative.BV was found in 114 cases(6.44%).The proportion of BV was 11.57%in HR-HPV positive group and 4.27%in HR-HPV negative group.The proportion of BV was significantly different between the two groups(P<0.05).All the four indexes of microecology were positive(pH>4.5,sialidase positive,hydrogen peroxide positive,leukocyte esterase positive)in 98 cases(5.54%).In HR-HPV positive group,the composition ratio of all the four indexes of microecology was 8.54%,in HR-HPV negative group,the composition ratio of all the four indexes of microecology was 4.27%,and in vaginal microecology,the composition ratio of all the four indexes of microecology was statistically significant(P<0.05).Conclusion Bacterial vaginosis and vaginal microecology are closely related to HR-HPV infection.Reducing the occurrence of bacterial vaginosis,maintaining vaginal microecological balance,can reduce the infection rate of HR-HPV.
作者
陈忆
吴丹
李柱南
张峥嵘
许颖
林婧
CHEN Yi;WU Dan;LI Zhu′nan;ZHANG Zhengrong;XU Ying;LIN Jing(Cervical Special Disease Diagnosis and Treatment Center,the International Peace Maternity&Child Health Hospital of China Welfare Institute,Shanghai 200030,China)
出处
《中国医药导报》
CAS
2018年第21期86-89,共4页
China Medical Herald
基金
上海申康医院发展中心适宜技术联合开发推广应用项目(SHDC12016209)
上海市申康医院发展中心慢性病综合防治项目(SHDC12015312)
上海交通大学医学院附属国际和平妇幼保健院院级课题(GFY5615)
关键词
乳头状瘤病毒感染
阴道病细菌性
宫颈肿瘤
癌前状态
微环境
Papillomavirus infections
Vaginosis bacterial
Uterine cervical neoplasms
Precancerous lesions
Microenvironment
