摘要
目的探讨阴道微环境改变与宫颈病变的相关性。方法选取门诊就诊妇女为研究对象。根据病理学结果分组,研究组159例为宫颈组织病理学结果提示宫颈癌和低级别、高级别鳞状上皮内病变患者,对照组159例为宫颈组织病理学结果正常就诊者。检测两组研究对象阴道分泌物中人类乳头瘤病毒(HPV)、病原体及阴道微生态指标,结合病理结果进行比较分析。结果研究组中HPV、细菌性阴道病、需氧型阴道炎、滴虫检出率分别为88.05%、39.62%、33.33%和13.21%,明显高于对照组(P<0.05)。研究组患者阴道分泌物清洁度III-IV度、p H>4.5、菌群多样性异常(I、IV级)和过氧化氢阳性的比例分别为50.31%、55.35%、59.75%和72.33%,显著高于对照组(P<0.05)。结论阴道内病原体感染可能增加宫颈病变发生,阴道微环境改变是参与宫颈病变发生发展的重要因素之一。
Objective To research the correlation between cervical cancer and squamous intraepithelial lesion with the imbalance of vaginal microenvironment. Methods A total of 318 outpatients were assigned into two groups,of which 159 women diagnosed with cervical cancer or squamous intraepithelial lesion by pathology were selected as experi-mental group,and the other 159 women without cervical lesions were selected as control group. Results The detection rates of HPV,BV,AV, trichomonas of experiment group were 88. 05% ,39. 62% ,33. 33% and 13. 21% respectively, which significantly higher than those in control group （P 〈0. 05） . Proportion of experiment group with level III-IV of va-ginal cleanliness, pH value exceed 4. 5, level I or IV of flora diversity and H202 positive were 50. 31% ,55. 35% , 59.15% and 72. 33% respectively, which were significantly higher than those in control group （ P 〈 0. 05 ） . Conclusion Pathogen infection in vagina may increase the possibility of cervical lesions. Imbalance of Vaginal microenvironment may be one of the important factors of cervical lesions.
出处
《中国临床保健杂志》
CAS
2017年第3期247-250,共4页
Chinese Journal of Clinical Healthcare
基金
安徽省科技厅资助项目(1604f0804010)
关键词
宫颈疾病
阴道涂片
Uterine cervical diseases
Vaginal smears
