摘要
目的探讨阴道滴虫是否能增加高危人乳头瘤病毒(HR-HPV)感染和宫颈癌发生的危险。方法对受检者进行液基细胞学检查和HR-HPV DNA检测,并在细胞学诊断中记录是否存在滴虫。对所有细胞学诊断非典型鳞状细胞(ASC)及以上病变、HR-HPV DNA阳性病例和部分细胞学阴性及HR-HPV DNA阴性病例进行阴道镜检查及活检。分别比较滴虫在HR-HPV DNA阳性组和阴性组、细胞学及组织学各级诊断中的存在率。结果在13024例受检者中有1687例(12.95%)涂片中有滴虫。滴虫存在率在HR-HPV DNA阳性组与阴性组中无显著统计学差异(P>0.05),在细胞学阴性病例组显著高于鳞状上皮内病变组(P<0.05),在组织学阴性病例组显著高于在≥CIN2病例组(P<0.05)。结论滴虫的存在不增加HR-HPV感染率,也不增加宫颈癌发生的危险。
Objective To investigate whether the presence of trichomonas can increase the risk of having high-risk human papillomavirus （HR-HPV） infection and cervical carcinoma. Methods All subjects were examined by liquid-based cytology and HR-HPV DNA tests. Of them, some negative cytological diagnosis caces and the cases of cytological diagnosis ≥ atypical squamous cells （ASC） or HPV DNA positive were taken colposcopic biopsy. The presence of trichomonas was recorded in the cytological diagnosis. We compared the presence rates of Trichomonas in grades of cytological diagnoses, grades of histological diagnosis, HPV DNA positive and negative groups, respectively. Results In the total of 13 024 subjects, 1 687（12. 95%）smears were found with trichomonas. There was no statistically significant difference in rates of trichomonas between in women with HR-HPV DNA positive and negative （P〉 0. 05）. But the rate was significantly higher in women with negative cytological diagnosis than in women with squamous intraepithelial lesions （P〉0. 05）. Women who had negative biopsy had a significantly higher trichomonas rate compared with women who had ≥CIN2 （P〈0. 05）. Conclusion The presence of trichomonas had no association with HR-HPV infection, neither increased the risk of having cervical carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第3期192-194,共3页
Cancer Research on Prevention and Treatment
关键词
宫颈癌
阴道滴虫
人乳头瘤病毒
Cervical carcinoma
Trichomonas vaginalis
Human papillomavirus
