摘要
目的:探讨CD44粘附分子在食管癌细胞中的表达情况及其临床意义。方法:采用流式细胞术检测65例食管癌细胞和食管切缘粘膜细胞中的CD44表达率,进行临床病理分析和统计学比较。结果:食管癌细胞的CD44表达率明显高于食管切缘粘膜细胞(P<0.001),中低分化食管癌细胞的CD44表达率高于高分化食管癌细胞(P<0.05),伴有淋巴结转移的食管癌细胞CD44表达率高于无淋巴结转移的食管癌细胞(P<0.05),Ⅲ～Ⅳ期食管癌细胞的CD44表达率高于Ⅱ期食管癌细胞(P<0.05)。结论:检测食管癌细胞的CD44表达水平,可为临床提供判断食管癌患者临床分期和预后的参考指标。
Purpose:To study the clinical significance of CD44 level in tumor cells of esophageal carcinoma patients. Methods:Sixty-five esophageal carcinoma cases were examined to observe the CD44 expression rate in tumor cells and nor- mal mucosal cells by flow cytometry.These data were clinicopathologically analyzed and compared with statistical methods. Results:The CD44 expression rate in tumors cells of esophageal carcinoma was obviously higher than that in normal mucosal cells (P<0.001).The CD44 expression rate in moderate-low differentiation tumor cells was higher than that in high differ- entiation tumor cells (P<0.05).The CD44 expression rate in tumor cells with metastasis of lymph node was higher than that in tumor cell without metastasis of lymph node (P<0.05).The CD44 expression rate in tumor cells of Ⅲ-Ⅳ stage pa- tients was higher than that in tumor cells of stage Ⅱ patients (P<0.05).Conclusions:The CD44 level in tumor cells of e- sophageal carcinoma patients is a useful index for clinical staging and judging prognosis.
出处
《中国癌症杂志》
CAS
CSCD
2002年第5期402-404,共3页
China Oncology
