摘要
目的 :探讨粘附分子CD4 4 在乳腺癌中的表达及其临床意义。方法 :采用逆转录聚合酶链反应(RT PCR)方法对 30例乳腺癌及 10例乳腺良性肿瘤组织中的CD4 4 基因的表达进行检测。结果 :①CD4 4 V6在乳腺癌中的表达显著性高于乳腺良性肿瘤 ;②乳腺癌组织中CD4 4 V6表达率明显高于CD4 4 S及CD4 4 V3;③Ⅲ、Ⅳ期乳腺癌CD4 4 V6表达显著高于Ⅰ、Ⅱ期乳腺癌 ;④有淋巴结转移的乳腺癌CD4 4 V6的表达明显高于无淋巴结转移者。结论 :CD4 4 V6在乳腺癌中的表达与乳腺癌的发生发展、浸润转移和预后密切相关 。
Objective To investigate the expression of molecule adhesion CD 44 in breast cancer and its clinical significance.Methods The expression of CD 44 were assayed by means of reverse transcriptase polymerase chain reaction(RT PCR)technique in 30 breast carcinomas and 10 benign breast tumor tissues.Results ①The expression of CD 44 V 6 in breast cancer was significantly higher than that in benign breast tumor.②The positive rate of CD 44 V 6 expression was significantly higher than that of CD 44 S,CD 44 V 3 in breast cancer.③Ⅲ-Ⅳ stages of breast cancer showed strong expressions of CD 44 V 6 than Ⅰ-Ⅱ stages of breast cancer.④CD 44 V 6 expression with lymph node metastasis was much higher than that without lymph node metastasis.Conclusions The expression of CD 44 V 6 is correlated with the process of invasion and metastasis in breast cancer,and might be a useful marker of breast cancer metastatic potential and the prognosis of the patients with breast cancer.
出处
《肿瘤防治杂志》
2001年第1期15-16,共2页
China Journal of Cancer Prevention and Treatment
基金
广西卫生厅资助课题!(9832 )
