摘要
Objective： Investigation of the relationship between P-glycoprotein （P-gp） and adhesion molecule CD44 as well as their clinical significance in gastric carcinoma. Methods： To examine the expressed level of P-gp and CD44 in 98 cases with gastric carcinoma by flow eytometry and evaluate their relationships with elinieopathologieal factors. Results： Among the 98 gastric carcinomas, 40 cases （40.8%） were P-gp negative （positive cells 〈25%）; 14 cases （14.2%） were 25%-40% expression of P-gp positive cells; 17 cases （17.3%） were 41%-60% expression of P-gp positive cells; 27 cases （27.5%） were the high expression （positive cells 〉60%） of P-gp in all patients with gastric carcinoma. When the tumor sizes were more than 6 cm, the P-gp positive of CD44 showed a significant difference （P〈0.05） in 35 cases with P-gp positive, compared with it in 24 cases with P-gp negative. When the tumors were in low-moderate differentiated gastric carcinoma, the expression of CD44 showed a significant difference （P〈0.05） in 44 cases with P-gp positive, as compared with it in 30 cases with P-gp negative. When the patients were in clinical Ⅲ-Ⅳ stage, the expression of CD44 showed a significant difference （P〈0.05） in 42 cases with P-gp positive, as compared with it in 30 cases with P-gp negative. When the patients with lymph node metastasis, their CD44 expression showed a significant difference （P〈0.05） in 46 cases with P-gp positive, compared with it in 32 cases with P-gp negative. When the tumors P-gp expressed positive, their CD44 expression will be increase. Conclusion： When the CD44 and P-gp both have the positive high expression, it will be significantly associated with the gastric carcinoma progression and metastasis, so both were a positive expression in gastric carcinoma, it might suggest a poor and unfavorable prognosis result.
基金
Supported by the ZheJiang Medical and Health Science Foundation （No.2005A09）.
