摘要
用嗜热菌酶酶促合成了一系列含门冬氨酸、谷氨酸的肽。实验证明,缩合反应中羧基组份中的门冬氨酸β-羧基或谷氨酸γ-羧基毋需保护。同时也研究了邻近氨基酸残基对缩合反应的影响。
A number of peptides were synthesized from the carboxyl component containing a
free side chain carboxyl group of aspartyl or glutamyl residue through thermolysin
catalysis. The effects of neighboring residues situated closely to a C-terminal glutamic
or aspartic acid in the carboxyl component on the formation of peptide bond were
studied. The efficiency of coupling by thermolysin varied with the nature of the amino
component and the carboxyl component. Strict sbereospecificity was observed.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1989年第3期266-269,共4页
Acta Chimica Sinica
