摘要
本文对青霉素G钾在猪体内的药物动力学特征进行了分析,6头猪体重29.3±1.1kg(平均值±标准差),按每kg体重静脉注射单剂量青霉素G钾15000IU,给药后分别在0,5,10,15,30,45min及1,1.5,2,3h收集血样,采用微生物法测定血清青霉素G的浓度。以电子计算机程序处理血药浓度—时间数据,血药浓度随时间变化符合二室开放模型,所得主要动力学参数为:分布半衰期(t1/2α)0.14±0.03h;消除半衰期(t1/2β)0.70±0.21h;表观分布容积(Vd)0.696±0.141 l/kg;体清除率(Cls)11.67±1.02 ml/(kg·min);药时曲线下面积(AUC)21.57±1.93h·IU/ml,本文还根据单剂量给药参数推算给药方案,供兽医临床参考。
Pharmacokinetic characteristics of potassium penicillin G were analysed in six pigs (mean±SD body weight 29. 3±1. 1 kg) with a single dose of 15 000 IU/kg body weight after intravenous administration. Blood samples were collected at 0, 5, 10, 15, 30, 45 minutes and 1, 1.5, 2, 3 hours after the drug was given. Serum concentrations of penicillin G were determined by microbiological method. A computer program was used to determine the pharmacokinetic parameters for the blood concentration- time data by compartmental analysis. The kinetic characteristics of penicillin G in swine were found to fit a two - compartment model . The elimination half - life (t1/2β) , apparent volume of distribution (Vd) and clearance (Cl2) of penicillin G were 0. 70±0. 21 h, 0. 696± 0. 144 1/kg and 11. 67±1. 02 ml/ (kg·min) (mean±SD) .respectively. According to the pharmacokinetic parameters of the single dose administrated intravenously, dosage regiments for clinical use of penicillin G in pigs were recommended.
出处
《华南农业大学学报》
CAS
CSCD
1991年第A11期54-59,共6页
Journal of South China Agricultural University
关键词
青霉素G钾
猪
药物动力学
Potassium penicillin G
Pigs
Pharmacokinetics
