摘要
目的 :研究非小细胞肺癌病灶中p5 3,ki- 6 7,p2 1的表达和淋巴结微转移灶之间的关系。方法 :对 39名病理证实为NSCLC的患者 ,取其肺肿瘤组织检测p5 3,ki- 6 7和 p2 1,再取其淋巴结检测细胞角蛋白CK ,以显示是否有淋巴结微转移灶。结果 :p5 3(- )和 (+)患者的CK阳性率分别为 33%和 71% ,Fisher’s精确卡方P =0 .0 4 5 ,ki- 6 7(- ) ,(+)者CK阳性率分别为 39%和 81% ,P =0 .0 2 ,p2 1为 2 8%和 81% ,P =0 .0 0 1。结论 :原发肺癌病灶中 p5 3蛋白 ,ki6 7,p2 1的表达和NSCLC患者淋巴结微转移灶的检出有必然的联系 ,p5 3(+)的患者淋巴结中检出微转移灶的机率要大于 p5 3(- )的患者 ,相同的情况也发生在ki- 6 7和p2 1两个基因上。
Objective: We studied the relationship between p53,ki-67,p21 and micrometastasis in lymph nodes of patients with non-small-cell lung cancer. Methods: In 39 NSCLC patients, we tested the p53,ki-67,p21,CK, using means of immunohistochemistry in the tumor and analyzed the relationship between these genes and CK. Results: The ratio of CK(+) in the patients with p53(-) is 33%, and that in the patients with p53(+) is 71%, P =0.045(Fisher's exact Chi-square). P values of ki-67 and p21 are 0.02 and 0.001 respectively. Conclusion: There is certain relationship between p53,ki-67,p21 and micrometastasis in lymph nodes of patients with NSCLC. The ratio of CK(+) in the patients with p53(+) is larger than that in the patients with p53(-). The same circumstances occurred in the patients with ki-67 or p21.
出处
《中国临床医学》
2002年第4期368-370,共3页
Chinese Journal of Clinical Medicine
