摘要
目的:探讨BRMS1的表达与乳腺癌腋窝淋巴结微转移的关系。方法:采用连续切片和CK-19联合检测86例腋窝淋巴结转移阴性的所有淋巴结微转移灶的情况,术后随访其复发情况,免疫组化检测乳腺癌组织中BRMS1的表达并分析其与淋巴结微转移及术后复发率的关系。结果:86例乳腺癌腋窝淋巴结转移阴性的689淋巴结中有48粒(6.97%)检测到微转移,其中阳性病例22例(25.58%),BRMS1的表达阴性的乳腺癌患者腋窝淋巴结微转移病例率(43.24%)和术后复发率(54.05%)远高于BRMS1表达阳性的乳腺癌患者(12.24%,8.16%),差异具有显著性,且呈明显的负相关。结论:BRMS1与腋窝淋巴结微转移密切相关,可以成为乳腺癌腋窝淋巴结微转移分子指标,并对乳腺癌的分期、预后、治疗具有重要的指导意义。
Objective： To investigate micro-metastasis in axillary lymph nodes and its relationship with BRMS1 genes expressin of the tumor tissue in breast cancer. Methods： Identifying the micro-metastases situation of the lymph node by serial sectioning and the expression of CK-19 in 89 cases of breast cancer tissue with lymph node metastasis-negative confirmed by conventional pathological findings, the postoperative follow-up was performed for 16 to 80 months. At the same time, detected the expression of BRMSI protein by immunohistochemistry and analyzed its relationship with lymph node micrometastasis and recurrence rate. Results： There were 48 （6.97%） detected micrometastases among the 689 lymph node from 86 cases of breast cancer axillary lymph node metastasis. 22 cases （25.58%） were positive, BRMS1 expression-negative breast cancer patients with axillary lymph node micrometastases in cases （43.24%） and recurrence rate （54.05%） is much higher than BRMS1 expression-positive breast cancer patients （12.24%, 8.16%）, the difference was significant, and there was a significant negative correlation. Conclusion： The expressin of BRMS1 is Closely related to axillary lymph nodes Micro-metastases in breast cancer, BRMS1 can become a molecular indicator of breast cancer＇s axillary lymph node micro-metastases, and it is great significance to breast cancer staging, prognosis, and treatment.
出处
《现代生物医学进展》
CAS
2012年第33期6503-6505,6571,共4页
Progress in Modern Biomedicine
基金
郴州市第一人民医院院级科研项目课题资助(N2009-017)
关键词
乳腺癌
BRMS1
腋窝淋巴结
微转移
Breast cancer
BRMS 1
Axillary lymph nodes
Micro-metastases
