摘要
【目的】为骨不连的实验研究建立一种客观的动物实验模型。【方法】选取纯种新西兰大白兔 ,在前臂桡骨中段截除 1 5cm骨段 (包括骨膜 ) ,骨断端用骨蜡封闭髓腔 ,10周后经大体标本、病理组织学及X线检查确定骨不连形成情况。【结果】大体标本肉眼观察、放射学检查及病理组织学检查均显示骨缺损区无骨性连接 ,为纤维瘢痕组织填充 ,骨端硬化。【结论】本实验所建立的动物模型 ,具有骨不连的病理改变 ,符合骨不连的要求 ,故可以认为是一种可靠而实用的实验性骨不连动物模型。
To establish an objective animal model for experimental study of bone nonunion. The bone segment of 1 5 cm in the middle part of radius of New Zealand rabbits was obtained by surgery. The bone marrow cavity was sealed by bone wax. Bone nonunion was observed by gross, histological and X ray examination 10 weeks after the procedure. The bone defect was filled by fiber scar tissue, without any bone tissue, and bone end sclerosis was demonstrated by gross, histological and X ray examination.[Conclusion] The pathological changes of the established animal model meet the demands of bone nonunion. It can serve as a reliable experimental model for the study of bone nonunion.
出处
《中山医科大学学报》
CSCD
北大核心
2002年第5期331-332,335,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
