摘要
GSTs是人体重要的肝脏解毒系统酶。本文应用生物素亲和素酶联免疫吸附法(BA—ELISA)检测了启东市肝癌高发区不同人群血清中总的GSTs浓度。该地区正常人群血清GSTs水平为(0.66±0.54ng/ml)明显高于北京地区正常人群(0.36±0.27ng/ml)。这可能与当地致癌物长期污染有关。肝癌家族、HBsAg携带者及AFP低持阳患者为启东肝癌高危险人群。他们血清中GSTs水平分别为1.25±1.46ng/ml、1.43±1.44ng/ml、2.81±1.76ng/ml。三组均高于正常人群,反映他们肝脏受到一定损伤。其中AFP低持阳组GSTs水平最高,这可能与癌前病变有关。57例肝癌患者GSTs水平为3.08±3.35ng/ml。此方法简便、快速,在肝癌高发区可望作为反映肝脏功能损伤及预测肝癌的一个新的生化指标。
In the present study, GSTs levels in serum of different groups of people in Qidong City, a high risk area of liver cancer, were determined by means of a biotin-avidin enzyme-linked immunoassay (BA-ELISA).The results showed that the GSTs level of normal subjects in Qidong city (0.66±0.54ng/ml) was higher than that in Beijing (0.36±0. 27ng/ml) Members of high cancer families, HBVsAg carriers and patients having a low-level fluctuating pattern of serum AFP are the population with high risk of liver cancer. The GSTs levels of 3 groups were 1.25±1.46, 1.43±1.44, and 2.81±1.76ng/ml, respectively. It was significantly higher than in the normal, The higher GSTs level in the patients having a low-level fluctuating pattern of serum AFP, may be nelatine to plecancenous hepatic lesions GSTs level in 57 liver cancer patients were 3.08±3.35ng/ml.This is a simple and rapid assay and coued be a useful aid the detection of liver dammage and in the prediction of liver cancer, especially in the high risk area of liver cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1991年第2期65-67,共3页
Cancer Research on Prevention and Treatment
