摘要
应用生物素—亲和素—酶联免疫吸附法（BA－ELISA）测定了36例喉癌病人血清谷胱甘肽S—转移酶（GST）的含量。结果表明．喉癌患者术前血清GST水平明显高于正常人（P＜0．01），与临床分期明显相关，Ⅲ、Ⅳ期患者显著高于Ⅰ、Ⅱ期患者（P＜0．05），与淋巴结转移、病理分级无关．手术切除肿瘤后血清GST水平迅速下降，术后14天恢复正常。提示血清GST可诈为喉癌的标志酶，监测血清GST浓度的变化对观察疗效和判断预后有重要意义。
The levels of serum glutathione S-transferase (GST) in 36 patients with laryngeal carcinoma were measured by enzyme linked immunosorbent assay (ELISA). The results were as follows:Serum GST levels in patients with laryngeal carcinoma were significantly higher than that in healthy control (P<0.01);The expression of serum GST in patients was correlated to clinical staging, they were significantly higher in the lesions of Ⅲ,Ⅳ stages than in that of Ⅰ.Ⅱstages (P<0.05); No relationship was found between GST expression and cervical lymph noddmetastasis and pathological grading; Serum levels of GST in patients were returned to normal 14 days after tumor resection.These results indicate that serum GST is a useful tumor marker and the measurernnt of serum GST in patients with laryngeal carcinoma is helpful for evaluating the efficacy of treatment and prognosis.
出处
《中国中西医结合耳鼻咽喉科杂志》
1996年第4期173-175,共3页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
关键词
喉肿瘤
癌
谷胱甘肽S
转移酶
Laryngeal Carcinoma Glutathione S-Transferase
