摘要
目的研究癌组织树突状细胞（DC）浸润与肾细胞癌淋巴结转移及预后的关系。方法对1994年-2000年在我院行手术治疗的69例肾癌患者的临床资料及随访记录进行统计,用S-100蛋白抗体ABC法免疫组化染色检测并计数癌组织DC细胞,分析二者之间的关系。结果术后2年未复发组癌组织内S-100+DC数量[（61.3±14.7个 /mm2]明显高于术后2年复发组[（31.4±11.6）个/mm2];有淋巴结转移的患者癌组织内S-100+DC数量[（28.8±10.4）个/mm2]明显低于无淋巴结转移的患者[（62.6±13.5）个 /mm2]。结论 肾细胞癌癌组织内DC细胞浸润密度和肾癌淋巴结转移及复发明显相关,是判断肾癌预后的良好指标。
Objective To investigate the relation of dendritic cell (DC) infiltration to the prognosis and lymph node metastasis of renal cell carcinoma. Method The tissue specimens were obtained from 69 patients with renal cell carcinomas, who were treated surgically from 1994 to 2000 in our hospital and followed up for over 2 years. ABC immunohistochemical method using S-100 protein antibody was employed to examine the tumor tissues and the DCs was counted. Results The patients showing no signs of tumor recurrence within 2 years postoperatively had significantly greater number of S-100+ DCs in the tumor tissues than that of patients with recurrence in 2 years (61.3+14.7/mm2vs 31.4+11.6/mm2). The number of S-100+ DCs of the group with lymph node metastasis was much lower than that of the group without the metastasis (28.8+10.4/mm2 vs 62.6 + 13.5/mm2). Conclusion The density of DC infiltration is closely related to the prognosis and lymph node metastasis, which may be used as a good indicator for prognostic assessment of renal cell carcinoma.
出处
《第一军医大学学报》
CSCD
北大核心
2002年第9期833-834,共2页
Journal of First Military Medical University
关键词
肾细胞癌
树突状细胞
免疫组化
免疫组化染色
预后
renal cell carcinoma
dendritic cells
metastasis/prognosis
immunohistochemistry
