摘要
[目的 ]了解壬基酚经消化道摄入后在大鼠体内的分布与清除过程。 [方法 ]对空腹和自由进食大鼠灌胃壬基酚后 ,不同时间剖杀动物 ,取血、肝、肾、睾丸和脑组织测定壬基酚含量。 [结果 ]空腹大鼠灌胃后壬基酚在血和睾丸中的清除符合一室模型 ,在肝、肾和脑组织中的清除符合二室模型。在血、肝、肾、睾丸和脑组织中的平均滞留时间分别为2 8 12、19 47、3 1 91、2 9 64和 3 9 41h。自由摄食大鼠灌胃后壬基酚在血、肝、肾、睾丸和脑组织中的清除符合一室模型 ,其平均滞留时间分别为 43 16、47 13、3 8 12、44 5 5和 41 5 1h。 [结论 ]消化道摄入壬基酚后 ,壬基酚主要分布于实质脏器中 ;壬基酚从体内的消除途径主要为经肝脏清除 ;
To probe the distribution and clearance of nonylphenol (NP),which was administered by gavage in rats. NP was administered to rats with or without feeding overnight by gavage. The rats were sacrificed at different time and the concentrations of NP in blood,liver,testis and brain were measured. In the group of rats without feeding:the clearance models in blood and testes were one compartment models,and in liver,kidney and brain were two compartment models. The mean retention time (MRT) in blood,liver,kidney,testis and brain was 28 12,19 47,31 91,29 64 and 39 41 hrs,respectively. In the group of rats with feeding:the clearance models of NP in blood,liver,kidney,testis and brain were one compartment models,and the MRT was 43 16,47 13,38 12,44 55 and 41 51 hrs,respectively. [Conclusion] NP administered by oral gavage intends to be distributed to all tissues,the main clearance route is by liver,and food components could decrease the NP clearance rates.
出处
《环境与职业医学》
CAS
北大核心
2002年第4期228-230,共3页
Journal of Environmental and Occupational Medicine
